RAD52

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]

RAD52

Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.

Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIGI:MGI
Biological Process cellular response to oxidative stressManual Assertion Based On ExperimentIDA:MGI
Biological Process DNA double-strand break processing involved in repair via single-strand annealingManual Assertion Based On ExperimentIDA:MGI
Biological Process DNA recombinase assemblyIEA:InterPro
Biological Process DNA recombinationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process double-strand break repairManual Assertion Based On ExperimentTAS:ProtInc
Biological Process double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process double-strand break repair via single-strand annealingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitotic recombinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of nucleotide-excision repairManual Assertion Based On ExperimentIDA:MGI

Nucleus

Phosphorylated upon DNA damage by ABL1, and probably by ATM or ATR.