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Mouse Anti-RAD52 Recombinant Antibody (5E11E7) (CBMAB-R1137-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
5E11E7
Antibody Isotype
IgG1
Application
ELISA, WB, IF, FC

Basic Information

Immunogen
Recombinant fragment of human RAD52 expressed in E. Coli
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
0.05% Sodium azide

Target

Full Name
RAD52
Introduction
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]
Entrez Gene ID
5893
UniProt ID
P43351
Alternative Names
RAD52 Homolog, DNA Repair Protein; RAD52 (S. Cerevisiae) Homolog; RAD52 Homolog (S. Cerevisiae);
Function
Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.
Biological Process
Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIGI:MGI
Biological Process cellular response to oxidative stressManual Assertion Based On ExperimentIDA:MGI
Biological Process DNA double-strand break processing involved in repair via single-strand annealingManual Assertion Based On ExperimentIDA:MGI
Biological Process DNA recombinase assemblyIEA:InterPro
Biological Process DNA recombinationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process double-strand break repairManual Assertion Based On ExperimentTAS:ProtInc
Biological Process double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process double-strand break repair via single-strand annealingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitotic recombinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of nucleotide-excision repairManual Assertion Based On ExperimentIDA:MGI
Cellular Location
Nucleus
PTM
Phosphorylated upon DNA damage by ABL1, and probably by ATM or ATR.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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