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QSOX1

This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene.
Full Name
quiescin Q6 sulfhydryl oxidase 1
Function
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:30367560, PubMed:23867277).
Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:30367560, PubMed:22801504, PubMed:23867277).
In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:30367560, PubMed:23867277).
Biological Process
Biological Process extracellular matrix assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of macroautophagyManual Assertion Based On ExperimentIMP:CACAO
Biological Process protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform 1
Golgi apparatus membrane
Secreted
A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor.
Isoform 2
Secreted
Found in the extracellular medium of quiescent cells but is not found in proliferating cells.
Topology
Helical: 710-730
PTM
N-glycosylated (PubMed:17331072, PubMed:29757379).
O-glycosylated on Thr and Ser residues (PubMed:29757379).

Anti-QSOX1 antibodies

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Target: QSOX1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC3-124
Application*: WB, ICC, P, C, E
Target: QSOX1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1F5C7H
Application*: FC
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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