Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-QSOX1 Recombinant Antibody (1F5C7H) (CBMAB-1857-YC)


See all QSOX1 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F5C7H
Antibody Isotype
IgG2a
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
quiescin Q6 sulfhydryl oxidase 1
Introduction
Qsox1 is a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. Qsox1 catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Qsox1 may contribute to disulfide bond formation in a variety of secreted proteins. Qsox1 plays an important role in growth regulation.
Entrez Gene ID
5768
UniProt ID
O00391
Alternative Names
Q6; QSCN6
Function
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:30367560, PubMed:23867277).
Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:30367560, PubMed:22801504, PubMed:23867277).
In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:30367560, PubMed:23867277).
Biological Process
Biological Process extracellular matrix assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of macroautophagyManual Assertion Based On ExperimentIMP:CACAO
Biological Process protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform 1
Golgi apparatus membrane
Secreted
A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor.
Isoform 2
Secreted
Found in the extracellular medium of quiescent cells but is not found in proliferating cells.
Topology
Helical: 710-730
PTM
N-glycosylated (PubMed:17331072, PubMed:29757379).
O-glycosylated on Thr and Ser residues (PubMed:29757379).
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-QSOX1 Recombinant Antibody (1F5C7H)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry