PRDX4

The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB.

peroxiredoxin 4

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.

Cell redox homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Extracellular matrix organizationIEA:Ensembl
I-kappaB phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Male gonad developmentIEA:Ensembl
Negative regulation of male germ cell proliferationIEA:Ensembl
Peptidyl-proline hydroxylation to 4-hydroxy-L-prolineIEA:Ensembl
Protein maturation by protein foldingIEA:Ensembl
Reactive oxygen species metabolic processIEA:Ensembl
Response to oxidative stressIEA:Ensembl
SpermatogenesisIEA:Ensembl

Cytoplasm
Endoplasmic reticulum
Cotranslationally translocated to and retained within the endoplasmic reticulum. A small fraction of the protein is cytoplasmic.

The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond.