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Mouse Anti-PRDX4 Recombinant Antibody (9A3) (CBMAB-P2745-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
9A3
Antibody Isotype
IgG1
Application
ICC, IF, IHC, IHC-P, WB

Basic Information

Immunogen
Full length human recombinant protein of human PRDX4 (NP_006397) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
peroxiredoxin 4
Introduction
PRDX4 (Peroxiredoxin 4) is a protein coding gene. Diseases associated with PRDX4 include Hypoascorbemia. Among its related pathways are Innate Immune System and Folate Metabolism. Gene Ontology annotations related to this gene include protein homodimerization activity and antioxidant activity. An important paralog of the gene is PRDX3.
Entrez Gene ID
10549
UniProt ID
Q13162
Alternative Names
AOE372; HEL-S-97n; PRX-4; AOE37-2
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.
Biological Process
Cell redox homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Extracellular matrix organizationIEA:Ensembl
I-kappaB phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Male gonad developmentIEA:Ensembl
Negative regulation of male germ cell proliferationIEA:Ensembl
Peptidyl-proline hydroxylation to 4-hydroxy-L-prolineIEA:Ensembl
Protein maturation by protein foldingIEA:Ensembl
Reactive oxygen species metabolic processIEA:Ensembl
Response to oxidative stressIEA:Ensembl
SpermatogenesisIEA:Ensembl
Cellular Location
Cytoplasm
Endoplasmic reticulum
Cotranslationally translocated to and retained within the endoplasmic reticulum. A small fraction of the protein is cytoplasmic.
PTM
The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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