PPY

PPY is a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa.

pancreatic polypeptide

Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
The physiological role for the icosapeptide has not yet been elucidated.

Feeding behaviorManual Assertion Based On ExperimentIBA:GO_Central
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Protein secretionManual Assertion Based On ExperimentTAS:ProtInc

Secreted