PNMT

The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene.

Full Name

PNMT

Function

Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (PubMed:20496117).
Other substrates include phenylethanolamine and octopamine (PubMed:8812853, PubMed:16363801, PubMed:16277617).
Also methylates normetanephrine (By similarity).

Biological Process

Catecholamine biosynthetic processTAS:Reactome
Epinephrine biosynthetic processIEA:UniProtKB-UniPathway
MethylationIEA:UniProtKB-KW

Cellular Location

Cytosol

Anti-PNMT antibodies

Rabbit Anti-PNMT Recombinant Antibody (BA0338) (CBMAB-0665CQ)

Datasheet

SDS

Target: PNMT

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: BA0338

Application*: IF, WB

Mouse Anti-PNMT Recombinant Antibody (1D2) (CBMAB-0664CQ)

Datasheet

SDS

Target: PNMT

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat, Dog, Monkey

Clone: 1D2

Application*: IF, P, WB

Mouse Anti-PNMT Antibody (10BA11) (CBMAB-1495CQ)

Datasheet

SDS

Target: PNMT

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 10BA11

Application*: E, WB

Mouse Anti-PNMT Antibody (10BA9) (CBMAB-1493CQ)

Datasheet

SDS

Target: PNMT

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 10BA9

Application*: E, WB

Mouse Anti-PNMT Recombinant Antibody (3G4) (CBMAB-P2267-YC)

Datasheet

SDS

Target: PNMT

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3G4

Application*: E, IP

Mouse Anti-PNMT Recombinant Antibody (1C11) (CBMAB-P2265-YC)

Datasheet

SDS

Target: PNMT

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1C11

Application*: WB, E

Mouse Anti-PNMT Recombinant Antibody (1B7) (CBMAB-P2264-YC)

Datasheet

SDS

Target: PNMT

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1B7

Application*: WB, IF, F

Mouse Anti-PNMT Recombinant Antibody (1B11) (CBMAB-P2263-YC)

Datasheet

SDS

Target: PNMT

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 1B11

Application*: F, IF, P, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)