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Mouse Anti-PNMT Recombinant Antibody (1D2) (CBMAB-0664CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Dog, Monkey
Clone
1D2
Antibody Isotype
IgG2b
Application
IF, IHC-P, WB

Basic Information

Immunogen
Recombinant full length Human PNMT
Specificity
Human, Mouse, Rat, Dog, Monkey
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PNMT
Introduction
The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway,Which converts noradrenaline to adrenaline. Beta-carboline 2N-methyltransferase activity is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
Human5409
Mouse18948
Rat24661
Dog491023
Monkey697444
UniProt ID
HumanP11086
MouseP40935
RatP10937
DogF1PW89
MonkeyH9F4R9
Alternative Names
PENT; PNMTase
Function
Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (PubMed:20496117).
Other substrates include phenylethanolamine and octopamine (PubMed:8812853, PubMed:16363801, PubMed:16277617).
Also methylates normetanephrine (By similarity).
Biological Process
Catecholamine biosynthetic processTAS:Reactome
Epinephrine biosynthetic processIEA:UniProtKB-UniPathway
MethylationIEA:UniProtKB-KW
Cellular Location
Cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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