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PLVAP

Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability.
Full Name
PLVAP
Function
Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development.
Biological Process
Developmental processISS:UniProtKB
MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cellular extravasationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of vascular permeabilityManual Assertion Based On ExperimentIBA:GO_Central
Tumor necrosis factor-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Membrane, caveola
Cytoplasm, perinuclear region
Membrane-associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region.
Involvement in disease
Diarrhea 10, protein-losing enteropathy type (DIAR10):
An autosomal recessive, congenital diarrheal disorder characterized by intractable secretory diarrhea with massive protein loss due to leaky fenestrated capillaries, severe hypoalbuminemia, hypogammaglobulinemia, hypertriglyceridemia, and electrolyte abnormalities. Disease severity is variable and death in infancy may occur in severe cases. Some patients show facial dysmorphic features, and cardiac and renal abnormalities.
Topology
Cytoplasmic: 1-27
Helical: 28-48
Extracellular: 49-442

Anti-PLVAP antibodies

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Target: PLVAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb263
Application*: FC, IHC-F, IF, IP, WB
Target: PLVAP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0172
Application*: F, C, IF, IP, WB
Target: PLVAP
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYM-3061
Application*: WB
Target: PLVAP
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Human
Clone: MECA-32
Application*: P, IF, IH, IP, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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