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Rat Anti-PLVAP Antibody (MECA-32) (CBMAB-1492CQ)


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Summary

Host Animal
Rat
Specificity
Mouse, Human
Clone
MECA-32
Antibody Isotype
IgG2a
Application
IHC-P, IF, IHC, IP, WB

Basic Information

Immunogen
Lymph node stroma
Specificity
Mouse, Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PLVAP
Introduction
PLVAP (Plasmalemma Vesicle Associated Protein) involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability. Diseases associated with PLVAP include Breast Benign Neoplasm and Thoracic Benign Neoplasm.
Entrez Gene ID
Human83483
Mouse84094
UniProt ID
HumanQ9BX97
MouseQ91VC4
Alternative Names
Pv1
Function
Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development.
Biological Process
Developmental processISS:UniProtKB
MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cellular extravasationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of vascular permeabilityManual Assertion Based On ExperimentIBA:GO_Central
Tumor necrosis factor-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Membrane, caveola
Cytoplasm, perinuclear region
Membrane-associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region.
Involvement in disease
Diarrhea 10, protein-losing enteropathy type (DIAR10):
An autosomal recessive, congenital diarrheal disorder characterized by intractable secretory diarrhea with massive protein loss due to leaky fenestrated capillaries, severe hypoalbuminemia, hypogammaglobulinemia, hypertriglyceridemia, and electrolyte abnormalities. Disease severity is variable and death in infancy may occur in severe cases. Some patients show facial dysmorphic features, and cardiac and renal abnormalities.
Topology
Cytoplasmic: 1-27
Helical: 28-48
Extracellular: 49-442
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For research use only. Not intended for any clinical use.

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