PGRMC1

This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]

Progesterone Receptor Membrane Component 1

Component of a progesterone-binding protein complex (PubMed:28396637).
Binds progesterone (PubMed:25675345).
Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity).
Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036).

Associative learningIEA:Ensembl
Axon guidanceIEA:Ensembl
Heme biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
MemoryIEA:Ensembl
Modification of synaptic structureIEA:Ensembl
Negative regulation of synapse organizationIEA:Ensembl
Positive regulation of protein localization to plasma membraneIEA:Ensembl

Microsome membrane
Smooth endoplasmic reticulum membrane
Mitochondrion outer membrane

Lumenal: 1-24
Helical: 25-43
Cytoplasmic: 44-195