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Mouse Anti-PGRMC1 Monoclonal Antibody (3F7) (CBMAB-1442-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3F7
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant protein PGRMC1 (NP_006658.1, aa 96-195)with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Progesterone Receptor Membrane Component 1
Introduction
PGRMC1 is a putative membrane-associated progesterone steroid receptor which is expressed predominantly in the liver and kidney.
Entrez Gene ID
10857
UniProt ID
O00264
Alternative Names
IZA; MPR; Dap1; HPR6.6
Function
Component of a progesterone-binding protein complex (PubMed:28396637).
Binds progesterone (PubMed:25675345).
Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity).
Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036).
Biological Process
Associative learningIEA:Ensembl
Axon guidanceIEA:Ensembl
Heme biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
MemoryIEA:Ensembl
Modification of synaptic structureIEA:Ensembl
Negative regulation of synapse organizationIEA:Ensembl
Positive regulation of protein localization to plasma membraneIEA:Ensembl
Cellular Location
Microsome membrane
Smooth endoplasmic reticulum membrane
Mitochondrion outer membrane
Topology
Lumenal: 1-24
Helical: 25-43
Cytoplasmic: 44-195
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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