PATJ

This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.

PATJ, Crumbs Cell Polarity Complex Component

Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950).
Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097).
Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity).
Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity).
May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity).
May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950).

Establishment of apical/basal cell polarityISS:UniProtKB
Establishment or maintenance of epithelial cell apical/basal polarity3 PublicationsIC:ComplexPortal
Intracellular signal transduction1 PublicationNAS:UniProtKB
Microtubule organizing center organizationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of microtubule cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Tight junction assemblyISS:UniProtKB