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Mouse Anti-PATJ Recombinant Antibody (15D1) (CBMAB-0641-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
15D1
Antibody Isotype
IgG2b
Application
ELISA, MA

Basic Information

Immunogen
Recombinant protein fragment of INADL
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PATJ, Crumbs Cell Polarity Complex Component
Introduction
This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. The protein may regulate protein targeting, cell polarity and integrity of tight junctions. It may also regulate the surface expression and/or function of ASIC3 in sensory neurons.
Entrez Gene ID
10207
UniProt ID
Q8NI35
Alternative Names
Cipp; INADL; hINADL; InaD-like
Function
Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950).
Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097).
Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity).
Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity).
May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity).
May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950).
Biological Process
Establishment of apical/basal cell polarityISS:UniProtKB
Establishment or maintenance of epithelial cell apical/basal polarity3 PublicationsIC:ComplexPortal
Intracellular signal transduction1 PublicationNAS:UniProtKB
Microtubule organizing center organizationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of microtubule cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Tight junction assemblyISS:UniProtKB
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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