PARP4

PARP4 is poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.

Poly(ADP-Ribose) Polymerase Family Member 4

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.

Cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Cellular protein modification processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to DNA damage stimulus1 PublicationNAS:UniProtKB
DNA repairManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB
Protein ADP-ribosylation1 PublicationNAS:UniProtKB
Protein mono-ADP-ribosylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of telomerase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Response to xenobiotic stimulus1 PublicationNAS:UniProtKB

Cytoplasm
Nucleus
Cytoplasm, cytoskeleton, spindle
Also found in the nucleus, associated with mitotic spindles.