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Mouse Anti-PARP4 (AA 408-611) Recombinant Antibody (CBFYM-3044) (CBMAB-M3240-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-3044
Antibody Isotype
IgG2b, k
Application
ICC, IHC, WB

Basic Information

Immunogen
pET28a(+) expression vector containing aa408-611 of the p193 cDNA
Specificity
Human
Antibody Isotype
IgG2b, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA
Preservative
0.09% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 408-611

Target

Full Name
Poly(ADP-Ribose) Polymerase Family Member 4
Introduction
This gene encodes polytransferase-like 1 protein, which is capable of catalyzing a polyation reaction. This protein has a catalytic domain which is homologous to that of poly transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.
Entrez Gene ID
143
UniProt ID
Q9UKK3
Alternative Names
Poly(ADP-Ribose) Polymerase Family Member 4; ADP-Ribosyltransferase (NAD+; Poly (ADP-Ribose) Polymerase)-Like 1; ADP-Ribosyltransferase Diphtheria Toxin-Like 4; Von Willebrand Factor A Domain Containing 5C; PARP-Related/IalphaI-Related H5/Proline-Rich; Vault Poly(ADP-Ribose) Polymerase; 193 KDa Vault Protein; ADPRTL1; PARP-4; ARTD4; PARPL; VPARP; PH5P
Function
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.
Biological Process
Cell deathManual Assertion Based On ExperimentIMP:UniProtKB
Cellular protein modification processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to DNA damage stimulus1 PublicationNAS:UniProtKB
DNA repairManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentIMP:UniProtKB
Protein ADP-ribosylation1 PublicationNAS:UniProtKB
Protein mono-ADP-ribosylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of telomerase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Response to xenobiotic stimulus1 PublicationNAS:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Cytoplasm, cytoskeleton, spindle
Also found in the nucleus, associated with mitotic spindles.
More Infomation

Sung, H. Y., Han, J., Chae, Y. J., Ju, W., Kang, J. L., Park, A. K., & Ahn, J. H. (2023). Identification of a novel PARP4 gene promoter CpG locus associated with cisplatin chemoresistance. BMB reports, 56(6), 347.

Frigon, L., & Pascal, J. M. (2023). Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP. Nucleic Acids Research, 51(22), 12492-12507.

Kim, J. H., Lee, S., & Hong, Y. C. (2022). Modification Effect of PARP4 and ERCC1 Gene Polymorphisms on the Relationship between Particulate Matter Exposure and Fasting Glucose Level. International journal of environmental research and public health, 19(10), 6241.

Kirby, I. T., Person, A., & Cohen, M. (2021). Rational design of selective inhibitors of PARP4. RSC Medicinal Chemistry, 12(11), 1950-1957.

Kim, J. H., & Hong, Y. C. (2020). Modification of PARP4, XRCC3, and RAD51 gene polymorphisms on the relation between bisphenol A exposure and liver abnormality. International journal of environmental research and public health, 17(8), 2794.

Cirello, V., Colombo, C., Pogliaghi, G., Proverbio, M. C., Rossi, S., Mussani, E., ... & Fugazzola, L. (2019). Genetic variants of PARP4 gene and PARP4P2 pseudogene in patients with multiple primary tumors including thyroid cancer. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 816, 111672.

Prawira, A., Munusamy, P., Yuan, J., Chan, C. H. T., Koh, G. L., Shuen, T. W. H., ... & Lee, A. S. G. (2019). Assessment of PARP4 as a candidate breast cancer susceptibility gene. Breast Cancer Research and Treatment, 177, 145-153.

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For research use only. Not intended for any clinical use.

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