P53

Dmp53 shares significant amino acid identity with the DNA-binding domain of p53, including conservation of key residues commonly mutated in human cancer. Like p53, overexpression of Dmp53 induces apoptosis, and inhibition of Dmp53 function renders cells resistant to X ray–induced apoptosis. In contrast to mammalian p53, Dmp53 overexpression does not induce a G1 cell cycle block, and inhibition of Dmp53 activity does not affect X ray–induced cell cycle arrest.

p53