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OPRM1

This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains.
Full Name
OPIOID RECEPTOR MU 1
Biological Process
Acute inflammatory response to antigenic stimulusIEA:Ensembl
Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathwayISS:UniProtKB
Adenylate cyclase-inhibiting opioid receptor signaling pathwayIEA:Ensembl
Behavioral response to ethanolManual Assertion Based On ExperimentIMP:UniProtKB
Eating behaviorIEA:Ensembl
Estrous cycleIEA:Ensembl
Excitatory postsynaptic potentialIEA:Ensembl
G protein-coupled opioid receptor signaling pathwayISS:UniProtKB
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Negative regulation of cAMP-mediated signalingIDA:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of cytosolic calcium ion concentrationIDA:UniProtKB
Negative regulation of nitric oxide biosynthetic processIDA:UniProtKB
Negative regulation of Wnt protein secretionManual Assertion Based On ExperimentIMP:UniProtKB
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayISS:UniProtKB
Positive regulation of appetiteIEA:Ensembl
Positive regulation of cAMP-mediated signalingIDA:UniProtKB
Positive regulation of cytosolic calcium ion concentrationIDA:UniProtKB
Positive regulation of ERK1 and ERK2 cascadeISS:UniProtKB
Positive regulation of neurogenesisISS:UniProtKB
Positive regulation of nitric oxide biosynthetic processIDA:UniProtKB
Regulation of cellular response to stressManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of NMDA receptor activityISS:UniProtKB
Regulation of sensory perception of painIEA:Ensembl
Response to cocaineIEA:Ensembl
Response to foodIEA:Ensembl
Response to growth factorIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Response to radiationIEA:Ensembl
Sensory perception1 PublicationNAS:UniProtKB
Sensory perception of painISS:UniProtKB
Wound healingIEA:Ensembl
Cellular Location
Cell membrane
Cell projection, axon
Perikaryon
Cell projection, dendrite
Endosome
Is rapidly internalized after agonist binding.
Isoform 12
Cytoplasm
Topology
Extracellular: 1-68
Helical: 69-93
Cytoplasmic: 94-106
Helical: 107-131
Extracellular: 132-142
Helical: 143-165
Cytoplasmic: 166-185
Helical: 186-207
Extracellular: 208-230
Helical: 231-255
Cytoplasmic: 256-279
Helical: 280-306
Extracellular: 307-314
Helical: 315-338
Cytoplasmic: 339-400

Anti-OPRM1 antibodies

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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
Target: OPRM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYM-3040
Application*: WB
Target: OPRM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBFYM-3039
Application*: E, IP, IF, IH
Target: OPRM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBXO-0464
Application*: WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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