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Mouse Anti-OPRM1 Recombinant Antibody (CBFYM-3039) (CBMAB-M3235-FY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYM-3039
Antibody Isotype
IgG2b
Application
ELISA, IP, IF, IHC

Basic Information

Immunogen
HEK membranes co-expressing mouse mu and delta opioid receptors
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
OPIOID RECEPTOR MU 1
Introduction
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor. The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains.
Entrez Gene ID
Human4988
Mouse18390
Rat25601
UniProt ID
HumanP35372
MouseP42866
RatP33535
Alternative Names
Opioid Receptor Mu 1; Mu Opiate Receptor; M-OR-1; MOR1; MOP; Mu Opioid Receptor HMOR-1a; Mu-Type Opioid Receptor; Opioid Receptor, Mu 1
Biological Process
Acute inflammatory response to antigenic stimulusIEA:Ensembl
Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathwayISS:UniProtKB
Adenylate cyclase-inhibiting opioid receptor signaling pathwayIEA:Ensembl
Behavioral response to ethanolManual Assertion Based On ExperimentIMP:UniProtKB
Eating behaviorIEA:Ensembl
Estrous cycleIEA:Ensembl
Excitatory postsynaptic potentialIEA:Ensembl
G protein-coupled opioid receptor signaling pathwayISS:UniProtKB
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Negative regulation of cAMP-mediated signalingIDA:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of cytosolic calcium ion concentrationIDA:UniProtKB
Negative regulation of nitric oxide biosynthetic processIDA:UniProtKB
Negative regulation of Wnt protein secretionManual Assertion Based On ExperimentIMP:UniProtKB
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayISS:UniProtKB
Positive regulation of appetiteIEA:Ensembl
Positive regulation of cAMP-mediated signalingIDA:UniProtKB
Positive regulation of cytosolic calcium ion concentrationIDA:UniProtKB
Positive regulation of ERK1 and ERK2 cascadeISS:UniProtKB
Positive regulation of neurogenesisISS:UniProtKB
Positive regulation of nitric oxide biosynthetic processIDA:UniProtKB
Regulation of cellular response to stressManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of NMDA receptor activityISS:UniProtKB
Regulation of sensory perception of painIEA:Ensembl
Response to cocaineIEA:Ensembl
Response to foodIEA:Ensembl
Response to growth factorIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Response to radiationIEA:Ensembl
Sensory perception1 PublicationNAS:UniProtKB
Sensory perception of painISS:UniProtKB
Wound healingIEA:Ensembl
Cellular Location
Cell membrane
Cell projection, axon
Perikaryon
Cell projection, dendrite
Endosome
Is rapidly internalized after agonist binding.
Isoform 12
Cytoplasm
Topology
Extracellular: 1-68
Helical: 69-93
Cytoplasmic: 94-106
Helical: 107-131
Extracellular: 132-142
Helical: 143-165
Cytoplasmic: 166-185
Helical: 186-207
Extracellular: 208-230
Helical: 231-255
Cytoplasmic: 256-279
Helical: 280-306
Extracellular: 307-314
Helical: 315-338
Cytoplasmic: 339-400
More Infomation

Salimando, G. J., Tremblay, S., Kimmey, B. A., Li, J., Rogers, S. A., Wojick, J. A., ... & Corder, G. (2023). Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types. Nature Communications, 14(1), 5632.

Zheng, S., Ishii, K., Masuda, T., Matsunaga, M., Noguchi, Y., Yamasue, H., & Ohtsubo, Y. (2022). Mu opioid receptor gene (OPRM1) moderates the influence of perceived parental attention on social support seeking. Adaptive Human Behavior and Physiology, 8(3), 281-295.

Zheng, S., Ishii, K., Masuda, T., Matsunaga, M., Noguchi, Y., Yamasue, H., & Ohtsubo, Y. (2022). Mu opioid receptor gene (OPRM1) moderates the influence of perceived parental attention on social support seeking. Adaptive Human Behavior and Physiology, 8(3), 281-295.

Gaddis, N., Mathur, R., Marks, J., Zhou, L., Quach, B., Waldrop, A., ... & Johnson, E. O. (2022). Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond. Scientific reports, 12(1), 16873.

Toddes, C., Lefevre, E. M., Brandner, D. D., Zugschwert, L., & Rothwell, P. E. (2021). μ-Opioid receptor (Oprm1) copy number influences nucleus accumbens microcircuitry and reciprocal social behaviors. Journal of Neuroscience, 41(38), 7965-7977.

Tchalova, K., Sadikaj, G., Moskowitz, D. S., Zuroff, D. C., & Bartz, J. A. (2021). Variation in the μ-opioid receptor gene (OPRM1) and experiences of felt security in response to a romantic partner’s quarrelsome behavior. Molecular Psychiatry, 26(8), 3847-3857.

Crews, K. R., Monte, A. A., Huddart, R., Caudle, K. E., Kharasch, E. D., Gaedigk, A., ... & Skaar, T. C. (2021). Clinical pharmacogenetics implementation consortium guideline for CYP2D6, OPRM1, and COMT genotypes and select opioid therapy. Clinical Pharmacology & Therapeutics, 110(4), 888-896.

Liu, S., Kang, W. J., Abrimian, A., Xu, J., Cartegni, L., Majumdar, S., ... & Pan, Y. X. (2021). Alternative pre-mRNA splicing of the mu opioid receptor gene, OPRM1: insight into complex mu opioid actions. Biomolecules, 11(10), 1525.

Zhou, H., Rentsch, C. T., Cheng, Z., Kember, R. L., Nunez, Y. Z., Sherva, R. M., ... & Gelernter, J. (2020). Association of OPRM1 functional coding variant with opioid use disorder: a genome-wide association study. JAMA psychiatry, 77(10), 1072-1080.

Popova, D., Desai, N., Blendy, J. A., & Pang, Z. P. (2019). Synaptic regulation by OPRM1 variants in reward neurocircuitry. Journal of Neuroscience, 39(29), 5685-5696.

Taqi, M. M., Faisal, M., & Zaman, H. (2019). OPRM1 A118G polymorphisms and its role in opioid addiction: implication on severity and treatment approaches. Pharmacogenomics and personalized medicine, 361-368.

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For research use only. Not intended for any clinical use.

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