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NUMB

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Full Name

NUMB, Endocytic Adaptor Protein

Function

Regulates clathrin-mediated receptor endocytosis (PubMed:18657069).
Plays a role in the process of neurogenesis (By similarity).
Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity).
Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity).
May also mediate local repair of brain ventricular wall damage (By similarity).

Biological Process

Adherens junction organizationIEA:Ensembl
AxonogenesisIEA:Ensembl
Lateral ventricle developmentISS:UniProtKB
Negative regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Neuroblast division in subventricular zoneISS:UniProtKB
Positive regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neurogenesisISS:UniProtKB
Regulation of postsynaptic neurotransmitter receptor internalizationIEA:Ensembl

Cellular Location

Cell membrane
Endosome membrane
Localizes to perinuclear endosomes in an AAK1-dependent manner.

PTM

Phosphorylated on Ser-276 and Ser-295 by CaMK1.
Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity).
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.

Anti-NUMB antibodies

Mouse Anti-NUMB Antibody (Cmnb-1) (CBMAB-1469CQ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Mouse, Human

Clone: Cmnb-1

Application*: IF, WB

Rabbit Anti-NUMB Recombinant Antibody (T.873.4) (CBMAB-N3980-WJ)

SDS

Target: NUMB

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: T.873.4

Application*: F, IC, IF, IP, WB

Rabbit Anti-NUMB Recombinant Antibody (S.925.4) (CBMAB-N3979-WJ)

SDS

Target: NUMB

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: S.925.4

Application*: F, IC, IF, IP, WB

Rabbit Anti-NUMB Recombinant Antibody (D5C2) (CBMAB-N3977-WJ)

SDS

Target: NUMB

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Frog, Zebrafish, Cattle, Horse

Clone: D5C2

Application*: WB, IF

Rabbit Anti-NUMB Recombinant Antibody (C29G11) (CBMAB-N3975-WJ)

SDS

Target: NUMB

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: C29G11

Application*: F, IF, IP, WB

Rabbit Anti-NUMB Recombinant Antibody (CBWJN-0488) (CBMAB-N3974-WJ)

SDS

Target: NUMB

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey, Mouse, Rat

Clone: CBWJN-0488

Application*: F, IF, IP, WB

Mouse Anti-NUMB Recombinant Antibody (6B2) (CBMAB-N3973-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 6B2

Application*: F, WB

Mouse Anti-NUMB Recombinant Antibody (5F6E1) (CBMAB-N3972-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 5F6E1

Application*: E, WB, IH

Mouse Anti-NUMB Recombinant Antibody (5A9) (CBMAB-N3970-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5A9

Application*: WB, IH

Mouse Anti-NUMB Recombinant Antibody (4D3) (CBMAB-N3967-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4D3

Application*: WB

Mouse Anti-NUMB Recombinant Antibody (4D10) (CBMAB-N3966-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 4D10

Application*: WB

Mouse Anti-NUMB Recombinant Antibody (4C6) (CBMAB-N3965-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 4C6

Application*: WB

Mouse Anti-NUMB Recombinant Antibody (CBWJN-0407) (CBMAB-N3964-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJN-0407

Application*: E, WB

Mouse Anti-NUMB Recombinant Antibody (3H8) (CBMAB-N3963-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 3H8

Application*: WB, IH

Mouse Anti-NUMB Recombinant Antibody (3B2) (CBMAB-N3962-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3B2

Application*: WB

Mouse Anti-NUMB Recombinant Antibody (2G12B7) (CBMAB-N3961-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: 2G12B7

Application*: E, WB, IH, IF

Mouse Anti-NUMB Recombinant Antibody (2C4) (CBMAB-N3958-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2C4

Application*: F, WB

Mouse Anti-NUMB Recombinant Antibody (2B9) (CBMAB-N3957-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2B9

Application*: WB, IH

Mouse Anti-NUMB Recombinant Antibody (1B5) (CBMAB-N3956-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 1B5

Application*: WB, IH

Mouse Anti-NUMB Recombinant Antibody (1A7) (CBMAB-N3955-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1A7

Application*: WB, F, IF

Mouse Anti-NUMB Recombinant Antibody (1A12) (CBMAB-N3954-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 1A12

Application*: WB

Mouse Anti-NUMB Recombinant Antibody (1A11) (CBMAB-N3953-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1A11

Application*: WB

Mouse Anti-NUMB Recombinant Antibody (2E8) (CBMAB-N3952-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2E8

Application*: P, WB

Mouse Anti-NUMB Recombinant Antibody (CBWJN-1614) (CBMAB-N3951-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBWJN-1614

Application*: WB, IC

Mouse Anti-NUMB Recombinant Antibody (3E5) (CBMAB-N3950-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Human

Clone: 3E5

Application*: WB, IH

Mouse Anti-NUMB Recombinant Antibody (CBWJN-1613) (CBMAB-N3949-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBWJN-1613

Application*: IC, WB

Mouse Anti-NUMB Recombinant Antibody (1E3) (CBMAB-N3948-WJ)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 1E3

Application*: WB

Mouse Anti-NUMB Recombinant Antibody (CBWJN-1612) (CBMAB-N3947-WJ)

SDS

Target: NUMB

Host: Mouse

Specificity: Mouse, Rat, Human, Dog

Clone: CBWJN-1612

Application*: WB, IF

Mouse Anti-NUMB Recombinant Antibody (CF318) (CBMAB-FT176LY)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CF318

Application*: ELISA, WB, IHC, IF

Mouse Anti-NUMB Recombinant Antibody (4A7-A6) (CBMAB-A6184-LY)

SDS

Target: NUMB

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4A7-A6

Application*: WB, E

NUMB Matched Antibody Pair (826) (APMAB-826LY)

SDS

Target: NUMB

Specificity: Human

NUMB Matched Antibody Pair (825) (APMAB-825LY)

SDS

Target: NUMB

Specificity: Human

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

Online Inquiry