NTRK3

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Neurotrophic Receptor Tyrosine Kinase 3

Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.

Activation of GTPase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Activation of protein kinase B activityManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular response to nerve growth factor stimulusManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to retinoic acidIEA:Ensembl
Cochlea developmentIEA:Ensembl
Heart developmentManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of astrocyte differentiationIEA:Ensembl
Negative regulation of cell deathIEA:Ensembl
Negative regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Neuron fate specificationIEA:Ensembl
Neuron migrationIEA:Ensembl
Positive regulation of actin cytoskeleton reorganizationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of MAP kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of positive chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentTAS:BHF-UCL
Regulation of postsynaptic density assemblyIEA:Ensembl
Regulation of presynapse assemblyIEA:Ensembl
Regulation of protein kinase B signalingManual Assertion Based On ExperimentIBA:GO_Central
Response to axon injuryIEA:Ensembl
Response to corticosteroneIEA:Ensembl
Response to ethanolIEA:Ensembl
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL

Membrane

Defects in NTRK3 are associated with susceptibility to congenital heart defects (CHD). A disease characterized by congenital developmental abnormalities involving structures of the heart. CHD are the most common major birth defects and the leading cause of death from congenital malformations.

Extracellular: 32-429
Helical: 430-453
Cytoplasmic: 454-839

Ligand-mediated auto-phosphorylation.