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Rat Anti-NTRK3 Recombinant Antibody (CBWJN-0842) (CBMAB-N3814-WJ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBWJN-0842
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neurotrophic Receptor Tyrosine Kinase 3
Introduction
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Entrez Gene ID
18213
UniProt ID
Q6VNS1
Alternative Names
Neurotrophic Receptor Tyrosine Kinase 3; Neurotrophic Tyrosine Kinase, Receptor, Type 3; EC 2.7.10.1; GP145-TrkC; TRKC; ETS Related Protein-Neurotrophic Receptor Tyrosine Kinase Fusion Protein; Neurotrophic Tyrosine Kinase Receptor Type 3; NT-3 Growth Factor Receptor;
Function
Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Biological Process
Activation of GTPase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Activation of protein kinase B activityManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular response to nerve growth factor stimulusManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to retinoic acidIEA:Ensembl
Cochlea developmentIEA:Ensembl
Heart developmentManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of astrocyte differentiationIEA:Ensembl
Negative regulation of cell deathIEA:Ensembl
Negative regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Neuron fate specificationIEA:Ensembl
Neuron migrationIEA:Ensembl
Positive regulation of actin cytoskeleton reorganizationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of MAP kinase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of positive chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentTAS:BHF-UCL
Regulation of postsynaptic density assemblyIEA:Ensembl
Regulation of presynapse assemblyIEA:Ensembl
Regulation of protein kinase B signalingManual Assertion Based On ExperimentIBA:GO_Central
Response to axon injuryIEA:Ensembl
Response to corticosteroneIEA:Ensembl
Response to ethanolIEA:Ensembl
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Membrane
Involvement in disease
Defects in NTRK3 are associated with susceptibility to congenital heart defects (CHD). A disease characterized by congenital developmental abnormalities involving structures of the heart. CHD are the most common major birth defects and the leading cause of death from congenital malformations.
Topology
Extracellular: 32-429
Helical: 430-453
Cytoplasmic: 454-839
PTM
Ligand-mediated auto-phosphorylation.
More Infomation

Dang, X., Xiang, T., Zhao, C., Tang, H., & Cui, P. (2022). EML4–NTRK3 fusion cervical sarcoma: a case report and literature review. Frontiers in Medicine, 9, 832376.

Csanyi-Bastien, M., Lanic, M. D., Beaussire, L., Ferric, S., François, A., Meseure, D., ... & Laé, M. (2021). Pan-TRK immunohistochemistry is highly correlated with NTRK3 gene rearrangements in salivary gland tumors. The American Journal of Surgical Pathology, 45(11), 1487-1498.

Zhang, Z., Yu, Y., Zhang, P., Ma, G., Zhang, M., Liang, Y., ... & Niu, H. (2021). Identification of NTRK3 as a potential prognostic biomarker associated with tumor mutation burden and immune infiltration in bladder cancer. BMC cancer, 21(1), 458.

Ogura, K., Somwar, R., Hmeljak, J., Magnan, H., Benayed, R., Momeni Boroujeni, A., ... & Ladanyi, M. (2021). Therapeutic potential of NTRK3 inhibition in desmoplastic small round cell tumor. Clinical Cancer Research, 27(4), 1184-1194.

Mortensen, L., Ordulu, Z., Dagogo-Jack, I., Bossuyt, V., Winters, L., Taghian, A., ... & Spring, L. M. (2021). Locally recurrent secretory carcinoma of the breast with NTRK3 gene fusion. The Oncologist, 26(10), 818-824.

Niu, Y., Lin, A., Luo, P., Tang, R., & Zhang, J. (2020). Prognosis of lung adenocarcinoma patients with NTRK3 mutations to immune checkpoint inhibitors. Frontiers in Pharmacology, 11, 552856.

Kao, Y. C., Sung, Y. S., Argani, P., Swanson, D., Alaggio, R., Tap, W., ... & Antonescu, C. R. (2020). NTRK3 overexpression in undifferentiated sarcomas with YWHAE and BCOR genetic alterations. Modern Pathology, 33(7), 1341-1349.

Xu, B., Haroon Al Rasheed, M. R., Antonescu, C. R., Alex, D., Frosina, D., Ghossein, R., ... & Katabi, N. (2020). Pan‐Trk immunohistochemistry is a sensitive and specific ancillary tool for diagnosing secretory carcinoma of the salivary gland and detecting ETV6–NTRK3 fusion. Histopathology, 76(3), 375-382.

Suurmeijer, A. J., Dickson, B. C., Swanson, D., Zhang, L., Sung, Y. S., Huang, H. Y., ... & Antonescu, C. R. (2019). The histologic spectrum of soft tissue spindle cell tumors with NTRK3 gene rearrangements. Genes, Chromosomes and Cancer, 58(11), 739-746.

Yamazaki, F., Nakatani, F., Asano, N., Wakai, S., Sekimizu, M., Mitani, S., ... & Yoshida, A. (2019). Novel NTRK3 fusions in fibrosarcomas of adults. The American journal of surgical pathology, 43(4), 523-530.

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For research use only. Not intended for any clinical use.

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