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NRF1

This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]

Full Name

nuclear respiratory factor 1

Function

Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.

Biological Process

Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

PTM

Phosphorylation enhances DNA binding.

Anti-NRF1 antibodies

Rabbit Anti-NRF1 Recombinant Antibody (D9K6P) (CBMAB-CP1764-LY)

SDS

Target: NRF1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: D9K6P

Application*: WB, IP, CI

Rabbit Anti-NRF1 Recombinant Antibody (D9K7R) (CBMAB-CP1765-LY)

SDS

Target: NRF1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: D9K7R

Application*: WB, IP

Mouse Anti-NRF1 Antibody (3D4) (CBMAB-0763-YC)

SDS

Target: NRF1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 3D4

Application*: CI, IP, WB, M

Mouse Anti-NRF1 Antibody (3H3) (CBMAB-0765-YC)

SDS

Target: NRF1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 3H3

Application*: CI, IP, WB, M

Mouse Anti-NRF1 Antibody (4A3) (CBMAB-0766-YC)

SDS

Target: NRF1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 4A3

Application*: IP, WB, M

Mouse Anti-NRF1 Recombinant Antibody (CBWJN-1546) (CBMAB-N3562-WJ)

SDS

Target: NRF1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CBWJN-1546

Application*: WB

Mouse Anti-NRF1 Recombinant Antibody (CBWJN-0191) (CBMAB-N3563-WJ)

SDS

Target: NRF1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBWJN-0191

Application*: WB

Mouse Anti-NRF1 Recombinant Antibody (2F9) (CBMAB-N3565-WJ)

SDS

Target: NRF1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2F9

Application*: E, WB

Mouse Anti-NRF1 Recombinant Antibody (CBWJN-0502) (CBMAB-N3566-WJ)

SDS

Target: NRF1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBWJN-0502

Application*: WB

Mouse Anti-NRF1 Recombinant Antibody (CBWJN-0569) (CBMAB-N3567-WJ)

SDS

Target: NRF1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBWJN-0569

Application*: WB, CI

Mouse Anti-NRF1 Recombinant Antibody (R157.1.3D4) (CBMAB-N3568-WJ)

SDS

Target: NRF1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: R157.1.3D4

Application*: IP, WB

Mouse Anti-NRF1 Recombinant Antibody (R157.1.3H3) (CBMAB-N3570-WJ)

SDS

Target: NRF1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: R157.1.3H3

Application*: IP, WB

Mouse Anti-NRF1 Recombinant Antibody (CBYJT-1511) (CBMAB-T0545-YJ)

SDS

Target: NRF1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJT-1511

Application*: WB

Mouse Anti-NRF1 Recombinant Antibody (CBYJT-1512) (CBMAB-T0546-YJ)

SDS

Target: NRF1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJT-1512

Application*: E, WB

Recombinant Mouse Anti-NRF1 Antibody (CBAb176) (CBMAB-Ab176-LY)

SDS

Target: NRF1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBAb176

Application*: WB

Mouse Anti-NRF1 Recombinant Antibody (2G4) (CBMAB-BR377LY)

SDS

Target: NRF1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: 2G4

Application*: FC, IHC-P, WB

Rabbit Anti-NRF1 Recombinant Antibody (CBWJN-1021) (CBMAB-N0522-WJ)

SDS

Target: NRF1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBWJN-1021

Application*: WB, IP, P, F, IC

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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