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Mouse Anti-NRF1 Recombinant Antibody (CBYJT-1511) (CBMAB-T0545-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1511
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
This antibody detects endogenous levels of NRF1, and does not cross-react with related proteins
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 0.1% BSA, 50% Glycerol
Preservative
0.2% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nuclear respiratory factor 1
Introduction
NRF1 is a protein that homodimerizes and plays a role as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. NRF1 has also been associated with the regulation of neurite outgrowth.
Entrez Gene ID
4899
UniProt ID
Q16656
Alternative Names
Nuclear Respiratory Factor 1; Alpha Palindromic-Binding Protein; ALPHA-PAL; NRF-1
Function
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Biological Process
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
PTM
Phosphorylation enhances DNA binding.
More Infomation

Perez, C. M., Gong, Z., Yoo, C., Roy, D., Deoraj, A., & Felty, Q. (2024). Inhibitor of DNA Binding Protein 3 (ID3) and Nuclear Respiratory Factor 1 (NRF1) Mediated Transcriptional Gene Signatures Are Associated with the Severity of Cerebral Amyloid Angiopathy. Molecular Neurobiology, 61(2), 835-882.

Lee, Y. H., Wu, R. C., Mai, H. C., Huang, W. L., Wu, C. H., Yang, Y. L., ... & Lin, V. C. (2023). The regulatory role of nuclear Respiratory factor 1 in bladder cancer cells. Anticancer Research, 43(4), 1521-1531.

Wang, D., Wan, B., Zhang, X., Sun, P., Lu, S., Liu, C., & Zhu, L. (2022). Nuclear respiratory factor 1 promotes the growth of liver hepatocellular carcinoma cells via E2F1 transcriptional activation. BMC gastroenterology, 22(1), 198.

Wu, C. H., Hsieh, P. F., Lee, Y. H., Kuo, W. W. T., Wu, R. C. Y., Lin, Y. Y., ... & Lin, V. C. (2022). Nuclear respiratory factor 1 overexpression inhibits proliferation and migration of PC3 prostate cancer cells. Cancer Genomics & Proteomics, 19(5), 614-623.

Li, H., Niu, N., Yang, J., Dong, F., Zhang, T., Li, S., & Zhao, W. (2021). Nuclear respiratory factor 1 protects H9C2 cells against hypoxia‐induced apoptosis via the death receptor pathway and mitochondrial pathway. Cell Biology International, 45(8), 1784-1796.

Lu, Y., Ding, W., Wang, B., Wang, L., Kan, H., Wang, X., ... & Zhu, L. (2020). Positive regulation of human PINK1 and Parkin gene expression by nuclear respiratory factor 1. Mitochondrion, 51, 22-29.

Alam, C., Hoque, M. T., Sangha, V., & Bendayan, R. (2020). Nuclear respiratory factor 1 (NRF‐1) upregulates the expression and function of reduced folate carrier (RFC) at the blood‐brain barrier. The FASEB Journal, 34(8), 10516-10530.

Bhawe, K., Felty, Q., Yoo, C., Ehtesham, N. Z., Hasnain, S. E., Singh, V. P., ... & Roy, D. (2020). Nuclear respiratory factor 1 (NRF1) transcriptional activity-driven gene signature association with severity of astrocytoma and poor prognosis of glioblastoma. Molecular neurobiology, 57, 3827-3845.

Ayeleso, A. O., Adepoju, A. E., & Mukwevho, E. (2020). Nuclear respiratory factor-1 (NRF-1), a versatile therapeutic target: influence of plant metabolites. African journal of biomedical research, 23(1), 1-8.

Niu, N., Li, Z., Zhu, M., Sun, H., Yang, J., Xu, S., ... & Song, R. (2019). Effects of nuclear respiratory factor‑1 on apoptosis and mitochondrial dysfunction induced by cobalt chloride in H9C2 cells. Molecular medicine reports, 19(3), 2153-2163.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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