NR5A2

The protein encoded by this gene is a DNA-binding zinc finger transcription factor and is a member of the fushi tarazu factor-1 subfamily of orphan nuclear receptors. The encoded protein is involved in the expression of genes for hepatitis B virus and cholesterol biosynthesis, and may be an important regulator of embryonic development.

NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A MEMBER 2

Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957).
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38 (By similarity).

Bile acid metabolic processIEA:Ensembl
Calcineurin-mediated signalingIEA:Ensembl
Cellular response to leukemia inhibitory factorIEA:Ensembl
Cholesterol homeostasisIEA:Ensembl
Embryo development ending in birth or egg hatchingManual Assertion Based On ExperimentTAS:UniProtKB
Epithelial cell differentiationIEA:Ensembl
Homeostatic process1 PublicationNAS:UniProtKB
Hormone-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Pancreas morphogenesisIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of viral genome replicationManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of cell population proliferationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central

Nucleus

Sumoylated by SUMO1 at Lys-270 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation.