NKX2-2

The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]

NK2 Homeobox 2

Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity).
May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity).

Astrocyte differentiationIEA:Ensembl
Brain developmentManual Assertion Based On ExperimentTAS:ProtInc
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Digestive tract developmentIEA:Ensembl
Negative regulation of neuron differentiationIEA:Ensembl
Neuron fate specificationIEA:Ensembl
Oligodendrocyte developmentIEA:Ensembl
Optic nerve developmentIEA:Ensembl
Pancreatic A cell fate commitmentIEA:Ensembl
Pancreatic PP cell fate commitmentIEA:Ensembl
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of neuron differentiationIEA:Ensembl
Positive regulation of oligodendrocyte differentiationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to glucoseIEA:Ensembl
Response to progesteroneIEA:Ensembl
Smoothened signaling pathwayIEA:Ensembl
Spinal cord motor neuron differentiationIEA:Ensembl
Spinal cord oligodendrocyte cell fate specificationIEA:Ensembl
Type B pancreatic cell developmentIEA:Ensembl
Type B pancreatic cell fate commitmentIEA:Ensembl
Ventral spinal cord interneuron fate determinationIEA:Ensembl

Nucleus