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Mouse Anti-NKX2-2 Recombinant Antibody (CBWJN-0759) (CBMAB-N0398-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-0759
Antibody Isotype
IgG1, κ
Application
FC, IF, IHC-P, CyTOF

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NK2 Homeobox 2
Introduction
The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]
Entrez Gene ID
4821
UniProt ID
O95096
Alternative Names
NK2 Homeobox 2; Homeobox Protein NK-2 Homolog B; NKX2.2; NKX2B; NK2 Transcription Factor Related, Locus 2 (Drosophila); NK2 Transcription Factor Related, Locus 2; NK2 Transcription Factor-Like Protein B; NK-2 (Drosophila) Homolog B; Homeobox Protein Nkx-2.2;
Function
Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity).
May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity).
Biological Process
Astrocyte differentiationIEA:Ensembl
Brain developmentManual Assertion Based On ExperimentTAS:ProtInc
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Digestive tract developmentIEA:Ensembl
Negative regulation of neuron differentiationIEA:Ensembl
Neuron fate specificationIEA:Ensembl
Oligodendrocyte developmentIEA:Ensembl
Optic nerve developmentIEA:Ensembl
Pancreatic A cell fate commitmentIEA:Ensembl
Pancreatic PP cell fate commitmentIEA:Ensembl
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of neuron differentiationIEA:Ensembl
Positive regulation of oligodendrocyte differentiationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to glucoseIEA:Ensembl
Response to progesteroneIEA:Ensembl
Smoothened signaling pathwayIEA:Ensembl
Spinal cord motor neuron differentiationIEA:Ensembl
Spinal cord oligodendrocyte cell fate specificationIEA:Ensembl
Type B pancreatic cell developmentIEA:Ensembl
Type B pancreatic cell fate commitmentIEA:Ensembl
Ventral spinal cord interneuron fate determinationIEA:Ensembl
Cellular Location
Nucleus
More Infomation

Kavitha, B., Srikanth, K., Singh, D., Gopi, S., Mohan, V., Chandra, N., & Radha, V. (2023). A novel stop-loss mutation in NKX2-2 gene as a cause of neonatal diabetes mellitus: molecular characterization and structural analysis. Acta Diabetologica, 1-6.

Seymour, P. A., & Serup, P. (2023). Differential use of the Nkx2. 2 NK2 domain in developing pancreatic islets and neurons. Genes & Development, 37(11-12), 451-453.

Abarinov, V., Levine, J. A., Churchill, A. J., Hopwood, B., Deiter, C. S., Guney, M. A., ... & Sussel, L. (2023). Major β cell-specific functions of NKX2. 2 are mediated via the NK2-specific domain. Genes & Development, 37(11-12), 490-504.

Berzanskyte, I., Riccio, F., Machado, C. B., Bradbury, E. J., & Lieberam, I. (2023). Enrichment of human embryonic stem cell-derived V3 interneurons using an Nkx2-2 gene-specific reporter. Scientific Reports, 13(1), 2008.

Zhang, C., Chen, Z., Zhang, D., Wang, X., Qiu, M., & Tan, Z. (2023). Role of Gltp in Maturation of Oligodendrocytes Under the Regulation of Nkx2. 2. Molecular Neurobiology, 1-12.

Machado, I., Charville, G. W., Yoshida, A., Navarro, S., Righi, A., Gambarotti, M., ... & Llombart-Bosch, A. (2022). Does PAX7 and NKX2. 2 immunoreactivity in Ewing sarcoma have prognostic significance?. Virchows Archiv, 480(4), 909-917.

Zhang, C., Huang, H., Chen, Z., Zhang, Z., Lu, W., & Qiu, M. (2020). The transcription factor NKX2-2 regulates oligodendrocyte differentiation through domain-specific interactions with transcriptional corepressors. Journal of Biological Chemistry, 295(7), 1879-1888.

Auerbach, A., Cohen, A., Ofek Shlomai, N., Weinberg-Shukron, A., Gulsuner, S., King, M. C., ... & Zangen, D. (2020). NKX2-2 mutation causes congenital diabetes and infantile obesity with paradoxical glucose-induced ghrelin secretion. The Journal of Clinical Endocrinology & Metabolism, 105(11), 3486-3495.

Mariyath, M. P., Shahi, M. H., Farheen, S., Tayyab, M., Khanam, N., & Ali, A. (2020). Novel homeodomain transcription factor Nkx2. 2 in the brain tumor development. Current Cancer Drug Targets, 20(5), 335-340.

Rooper, L. M., Sharma, R., Gocke, C. D., & Belchis, D. A. (2019). The utility of NKX2. 2 and TLE1 immunohistochemistry in the differentiation of Ewing sarcoma and synovial sarcoma. Applied Immunohistochemistry & Molecular Morphology, 27(3), 174-179.

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For research use only. Not intended for any clinical use.

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