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Mouse Anti-NKX2-2 Recombinant Antibody (CBWJN-1414) (CBMAB-N2566-WJ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBWJN-1414
Antibody Isotype
IgG2b
Application
WB, ICC

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NK2 Homeobox 2
Introduction
The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human4821
Mouse18088
Rat366214
UniProt ID
HumanO95096
MouseP42586
RatD3ZDQ2
Alternative Names
NK2 Homeobox 2; Homeobox Protein NK-2 Homolog B; NKX2.2; NKX2B; NK2 Transcription Factor Related, Locus 2 (Drosophila); NK2 Transcription Factor Related, Locus 2; NK2 Transcription Factor-Like Protein B; NK-2 (Drosophila) Homolog B; Homeobox Protein Nkx-2.2;
Function
Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity).
May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity).
Biological Process
Astrocyte differentiationIEA:Ensembl
Brain developmentManual Assertion Based On ExperimentTAS:ProtInc
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Digestive tract developmentIEA:Ensembl
Negative regulation of neuron differentiationIEA:Ensembl
Neuron fate specificationIEA:Ensembl
Oligodendrocyte developmentIEA:Ensembl
Optic nerve developmentIEA:Ensembl
Pancreatic A cell fate commitmentIEA:Ensembl
Pancreatic PP cell fate commitmentIEA:Ensembl
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of neuron differentiationIEA:Ensembl
Positive regulation of oligodendrocyte differentiationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to glucoseIEA:Ensembl
Response to progesteroneIEA:Ensembl
Smoothened signaling pathwayIEA:Ensembl
Spinal cord motor neuron differentiationIEA:Ensembl
Spinal cord oligodendrocyte cell fate specificationIEA:Ensembl
Type B pancreatic cell developmentIEA:Ensembl
Type B pancreatic cell fate commitmentIEA:Ensembl
Ventral spinal cord interneuron fate determinationIEA:Ensembl
Cellular Location
Nucleus
More Infomation

Kavitha, B., Srikanth, K., Singh, D., Gopi, S., Mohan, V., Chandra, N., & Radha, V. (2023). A novel stop-loss mutation in NKX2-2 gene as a cause of neonatal diabetes mellitus: molecular characterization and structural analysis. Acta Diabetologica, 1-6.

Seymour, P. A., & Serup, P. (2023). Differential use of the Nkx2. 2 NK2 domain in developing pancreatic islets and neurons. Genes & Development, 37(11-12), 451-453.

Abarinov, V., Levine, J. A., Churchill, A. J., Hopwood, B., Deiter, C. S., Guney, M. A., ... & Sussel, L. (2023). Major β cell-specific functions of NKX2. 2 are mediated via the NK2-specific domain. Genes & Development, 37(11-12), 490-504.

Berzanskyte, I., Riccio, F., Machado, C. B., Bradbury, E. J., & Lieberam, I. (2023). Enrichment of human embryonic stem cell-derived V3 interneurons using an Nkx2-2 gene-specific reporter. Scientific Reports, 13(1), 2008.

Zhang, C., Chen, Z., Zhang, D., Wang, X., Qiu, M., & Tan, Z. (2023). Role of Gltp in Maturation of Oligodendrocytes Under the Regulation of Nkx2. 2. Molecular Neurobiology, 1-12.

Machado, I., Charville, G. W., Yoshida, A., Navarro, S., Righi, A., Gambarotti, M., ... & Llombart-Bosch, A. (2022). Does PAX7 and NKX2. 2 immunoreactivity in Ewing sarcoma have prognostic significance?. Virchows Archiv, 480(4), 909-917.

Zhang, C., Huang, H., Chen, Z., Zhang, Z., Lu, W., & Qiu, M. (2020). The transcription factor NKX2-2 regulates oligodendrocyte differentiation through domain-specific interactions with transcriptional corepressors. Journal of Biological Chemistry, 295(7), 1879-1888.

Auerbach, A., Cohen, A., Ofek Shlomai, N., Weinberg-Shukron, A., Gulsuner, S., King, M. C., ... & Zangen, D. (2020). NKX2-2 mutation causes congenital diabetes and infantile obesity with paradoxical glucose-induced ghrelin secretion. The Journal of Clinical Endocrinology & Metabolism, 105(11), 3486-3495.

Mariyath, M. P., Shahi, M. H., Farheen, S., Tayyab, M., Khanam, N., & Ali, A. (2020). Novel homeodomain transcription factor Nkx2. 2 in the brain tumor development. Current Cancer Drug Targets, 20(5), 335-340.

Rooper, L. M., Sharma, R., Gocke, C. D., & Belchis, D. A. (2019). The utility of NKX2. 2 and TLE1 immunohistochemistry in the differentiation of Ewing sarcoma and synovial sarcoma. Applied Immunohistochemistry & Molecular Morphology, 27(3), 174-179.

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For research use only. Not intended for any clinical use.

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