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NDRG1

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Full Name
N-Myc Downstream Regulated 1
Function
Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.
Biological Process
Cellular response to hypoxia Source: UniProtKB
DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
Mast cell activation Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Peripheral nervous system myelin maintenance Source: Ensembl
Response to metal ion Source: ProtInc
Signal transduction Source: GO_Central
Cellular Location
Nucleus
Cytoskeleton
centrosome
cytosol
Plasma membrane
Cell membrane
Note: Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane.
Involvement in disease
Charcot-Marie-Tooth disease 4D (CMT4D):
A recessive demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4.
PTM
Under stress conditions, phosphorylated in the C-terminal on many serine and threonine residues. Phosphorylated in vitro by PKA. Phosphorylation enhanced by increased intracellular cAMP levels. Homocysteine induces dephosphorylation. Phosphorylation by SGK1 is cell cycle dependent.

Anti-NDRG1 antibodies

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Target: NDRG1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBNH-085
Application*: E, WB, IH, IF
Target: NDRG1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D98G11
Application*: WB, P, IF, F
Target: NDRG1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBWJN-0964
Application*: WB, IP, P, IC
Target: NDRG1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBWJN-0732
Application*: WB, F, IF
Target: NDRG1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-0060
Application*: F, IC, IH, IP, WB
Target: NDRG1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 11G4
Application*: WB, F, E, IF
Target: NDRG1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse
Clone: CBWJN-0180
Application*: IH, IP, WB
Target: NDRG1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2D7
Application*: E, IF, IH, WB
Target: NDRG1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2Q340
Application*: IH, WB
Target: NDRG1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: 3C165
Application*: E
Target: NDRG1
Host: Mouse
Specificity: Human
Clone: A-5
Application*: WB, IP, IF, E
Target: NDRG1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D10F8
Application*: WB
Target: NDRG1
Host: Rabbit
Specificity: Human, Mouse, Monkey
Clone: D3A12
Application*: WB, IP, P
Target: NDRG1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D6C2
Application*: WB
Target: NDRG1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D8G9
Application*: WB, IP, P, IF
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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