NAB2

This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq]

NAB2

Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).

Endochondral ossification Source: Ensembl
Myelination Source: Ensembl
Negative regulation of transcription by RNA polymerase III Source: MGI
Positive regulation of tau-protein kinase activity Source: ARUK-UCL
Regulation of epidermis development Source: Ensembl
Regulation of transcription, DNA-templated Source: GO_Central
Schwann cell differentiation Source: Ensembl

Nucleus
Note: Isoform 2 is not localized to the nucleus.

Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain.