Mouse Anti-NAB2 Antibody (2G1) (CBMAB-0696-YC)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2G1

Antibody Isotype

IgG2a

Application

IP, WB, MA

Basic Information

Immunogen

Recombinant protein

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

NAB2

Introduction

NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. NAB2 (NGFI-A binding protein 2) is a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. Transcriptional repression by NAB2 is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex.

Entrez Gene ID

4665

UniProt ID

Q15742

Alternative Names

AI451907

Function

Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).

Biological Process

Endochondral ossification Source: Ensembl
Myelination Source: Ensembl
Negative regulation of transcription by RNA polymerase III Source: MGI
Positive regulation of tau-protein kinase activity Source: ARUK-UCL
Regulation of epidermis development Source: Ensembl
Regulation of transcription, DNA-templated Source: GO_Central
Schwann cell differentiation Source: Ensembl

Cellular Location

Nucleus
Note: Isoform 2 is not localized to the nucleus.

PTM

Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain.

More Infomation

References

Ji, W. T., Hu, Y., & Wang, Y. (2022). Case report: Solitary fibrous tumor of the kidney with a NAB2-STAT6 fusion gene. Frontiers in Oncology, 12, 1045238.

Bieg, M., Moskalev, E. A., Will, R., Hebele, S., Schwarzbach, M., Schmeck, S., ... & Haller, F. (2021). Gene expression in solitary fibrous tumors (SFTs) correlates with anatomic localization and NAB2-STAT6 gene fusion variants. The American journal of pathology, 191(4), 602-617.

Park, Y. S., Kim, H. S., Kim, J. H., Choi, S. H., Kim, D. S., Ryoo, Z. Y., ... & Lee, S. (2020). NAB2-STAT6 fusion protein mediates cell proliferation and oncogenic progression via EGR-1 regulation. Biochemical and Biophysical Research Communications, 526(2), 287-292.

Han, P., Relav, L., & Price, C. A. (2020). Regulation of the early growth response-1 binding protein NAB2 in bovine granulosa cells and effect on connective tissue growth factor expression. Molecular and Cellular Endocrinology, 518, 111041.

Choi, S. Y., Oh, S. Y., Kang, S. H., Kang, S. M., Kim, J., Lee, H. J., ... & Hong, S. H. (2019). NAB 2-expressing cancer-associated fibroblast promotes HNSCC progression. Cancers, 11(3), 388.

Kim, J., Kang, S. M., Oh, S. Y., Lee, H. J., Lee, I., Hwang, J. C., & Hong, S. H. (2019). NGFI-A binding protein 2 promotes EGF-dependent HNSCC cell invasion. Cancers, 11(3), 315.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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