MYB

This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

MYB Proto-Oncogene, Transcription Factor

Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.

Cellular response to hydrogen peroxide Source: Ensembl
Cellular response to retinoic acid Source: Ensembl
Chromatin remodeling Source: UniProtKB
Mitotic cell cycle Source: GO_Central
Negative regulation of hematopoietic progenitor cell differentiation Source: ARUK-UCL
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of collagen biosynthetic process Source: Ensembl
Positive regulation of glial cell proliferation Source: Ensembl
Positive regulation of hepatic stellate cell activation Source: Ensembl
Positive regulation of hepatic stellate cell proliferation Source: Ensembl
Positive regulation of histone H3-K4 methylation Source: UniProtKB
Positive regulation of histone H3-K9 methylation Source: UniProtKB
Positive regulation of neuron apoptotic process Source: Ensembl
Positive regulation of smooth muscle cell proliferation Source: Ensembl
Positive regulation of testosterone secretion Source: Ensembl
Positive regulation of T-helper cell differentiation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of transforming growth factor beta production Source: Ensembl
Regulation of hematopoietic stem cell differentiation Source: Reactome
Regulation of transcription, DNA-templated Source: GO_Central
Response to hypoxia Source: Ensembl

Nucleus

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.
Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels.