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Mouse Anti-MYB Recombinant Antibody (MYB286) (CBMAB-C0946-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
MYB286
Antibody Isotype
IgG1, κ
Application
WB, FC, IF, IP

Basic Information

Immunogen
A synthetic peptide, corresponding to aa 119-135 (RRKVEQEGYPQESSKAG) of c-myb oncoprotein, coupled to KLH
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MYB Proto-Oncogene, Transcription Factor
Introduction
This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
4602
UniProt ID
P10242
Alternative Names
MYB Proto-Oncogene, Transcription Factor; V-Myb Avian Myeloblastosis Viral Oncogene Homolog; Proto-Oncogene C-Myb; Transcriptional Activator Myb; Oncogene AMV; C-Myb_CDS; C-Myb; Cmyb; EFG;
Function
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Biological Process
Cellular response to hydrogen peroxide Source: Ensembl
Cellular response to retinoic acid Source: Ensembl
Chromatin remodeling Source: UniProtKB
Mitotic cell cycle Source: GO_Central
Negative regulation of hematopoietic progenitor cell differentiation Source: ARUK-UCL
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of collagen biosynthetic process Source: Ensembl
Positive regulation of glial cell proliferation Source: Ensembl
Positive regulation of hepatic stellate cell activation Source: Ensembl
Positive regulation of hepatic stellate cell proliferation Source: Ensembl
Positive regulation of histone H3-K4 methylation Source: UniProtKB
Positive regulation of histone H3-K9 methylation Source: UniProtKB
Positive regulation of neuron apoptotic process Source: Ensembl
Positive regulation of smooth muscle cell proliferation Source: Ensembl
Positive regulation of testosterone secretion Source: Ensembl
Positive regulation of T-helper cell differentiation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of transforming growth factor beta production Source: Ensembl
Regulation of hematopoietic stem cell differentiation Source: Reactome
Regulation of transcription, DNA-templated Source: GO_Central
Response to hypoxia Source: Ensembl
Cellular Location
Nucleus
PTM
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.
Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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