MUC17

The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene.

MUC17

Probably plays a role in maintaining homeostasis on mucosal surfaces.

Cellular homeostasis Source: UniProtKB

Isoform 1:
Plasma membrane
Cell membrane
Isoform 2:
Secreted
Plasma membrane
Cell membrane

Extracellular: 26-4393
Helical: 4394-4414
Cytoplasmic: 4415-4493

Probably cleaved within the SEA domain.
N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.