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Mouse Anti-MUC17 Antibody (9BA7) (CBMAB-1433CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
9BA7
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Immunogen
Recombinant Peptide (aa 4015-4401)
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MUC17
Introduction
The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Diseases associated with MUC17 include Biliary Papillomatosis and Colorectal Cancer 1. Among its related pathways are O-linked glycosylation and HIV Life Cycle.
Entrez Gene ID
140453
UniProt ID
Q685J3
Alternative Names
MUC3; MUC-3; MUC-17
Function
Probably plays a role in maintaining homeostasis on mucosal surfaces.
Biological Process
Cellular homeostasis Source: UniProtKB
Cellular Location
Isoform 1:
Plasma membrane
Cell membrane
Isoform 2:
Secreted
Plasma membrane
Cell membrane
Topology
Extracellular: 26-4393
Helical: 4394-4414
Cytoplasmic: 4415-4493
PTM
Probably cleaved within the SEA domain.
N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.
More Infomation

Lin, S., Ruan, H., Qin, L., Zhao, C., Gu, M., Wang, Z., ... & Wang, J. (2023). Acquired resistance to EGFR-TKIs in NSCLC mediates epigenetic downregulation of MUC17 by facilitating NF-κB activity via UHRF1/DNMT1 complex. International Journal of Biological Sciences, 19(3), 832.

Machado, G. C., & Ferrer, V. P. (2023). MUC17 mutations and methylation are associated with poor prognosis in adult-type diffuse glioma patients. Journal of the Neurological Sciences, 452, 120762.

Layunta, E., Jäverfelt, S., Dolan, B., Arike, L., & Pelaseyed, T. (2021). IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during weaning. Cell Reports, 34(7).

Jonckheere, N., Vincent, A., Neve, B., & Van Seuningen, I. (2021). Mucin expression, epigenetic regulation and patient survival: A toolkit of prognostic biomarkers in epithelial cancers. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1876(1), 188538.

Yang, B., Wu, A., Hu, Y., Tao, C., Wang, J. M., Lu, Y., & Xing, R. (2019). Mucin 17 inhibits the progression of human gastric cancer by limiting inflammatory responses through a MYH9-p53-RhoA regulatory feedback loop. Journal of Experimental & Clinical Cancer Research, 38(1), 1-13.

Lin, S., Zhang, Y., Hu, Y., Yang, B., Cui, J., Huang, J., ... & Lu, Y. (2019). Epigenetic downregulation of MUC17 by H. pylori infection facilitates NF-κB-mediated expression of CEACAM1-3S in human gastric cancer. Gastric Cancer, 22, 941-954.

Schneider, H., Berger, E., Dolan, B., Martinez-Abad, B., Arike, L., Pelaseyed, T., & Hansson, G. C. (2019). The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane. Biochemical Journal, 476(16), 2281-2295.

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For research use only. Not intended for any clinical use.

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