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MSR1

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
Full Name
Macrophage Scavenger Receptor 1
Function
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254).

Isoform III does not internalize acetylated LDL (PubMed:9548586).
Biological Process
Amyloid-beta clearance Source: ARUK-UCL
Cellular response to organic cyclic compound Source: Ensembl
Cholesterol transport Source: BHF-UCL
Lipoprotein transport Source: Ensembl
Negative regulation of gene expression Source: ARUK-UCL
Phagocytosis, engulfment Source: ARUK-UCL
Plasma lipoprotein particle clearance Source: BHF-UCL
Positive regulation of cholesterol storage Source: BHF-UCL
Positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Receptor-mediated endocytosis Source: ARUK-UCL
Cellular Location
Membrane
Involvement in disease
Prostate cancer (PC):
A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
Barrett esophagus (BE):
A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.
Topology
Cytoplasmic: 1-50
Helical: 51-76
Extracellular: 77-451

Anti-MSR1 antibodies

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Target: MSR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9E5
Application*: IH, WB
Target: MSR1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 2G9
Application*: E, WB
Target: MSR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 351620
Application*: B, WB
Target: MSR1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 268318
Application*: F, WB
Target: MSR1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 351615
Application*: F, WB
Target: MSR1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBHb045
Application*: FC, IHC-F, FuncS, IP, WB
Target: MSR1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D8K4E
Application*: WB
Target: MSR1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 2G8
Application*: WB, E
Target: MSR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: PSL204
Application*: F
Target: MSR1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBWJC-4179
Application*: F
Target: MSR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-4178
Application*: P
Target: MSR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYY-C1257
Application*: WB
Target: MSR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C0576
Application*: F
Target: MSR1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse, Pig
Clone: CBXS-3332
Application*: F
Target: MSR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1794
Application*: WB, B
Target: MSR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5969
Application*: WB, IH
Target: MSR1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1793
Application*: F
Target: MSR1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXS-1747
Application*: F
Target: MSR1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0855
Application*: F
Target: MSR1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Fish, Mouse, Pig
Clone: 2F8
Application*: F
Target: MSR1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYM-2665
Application*: E, F, FN, C, IP, WB
Target: MSR1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYM-2664
Application*: F, C, IP, WB
Target: MSR1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBFYM-2663
Application*: E, WB
Target: MSR1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2662
Application*: E
Target: MSR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2661
Application*: IH, WB, N
Target: MSR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2660
Application*: P, WB
Target: MSR1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYM-0739
Application*: E, IH, IP, WB
Target: MSR1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYM-0471
Application*: F
Target: MSR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBFYM-0441
Application*: F
Target: MSR1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse, Pig
Clone: CBFYM-0116
Application*: E, F, IF, C, IP, WB
Target: MSR1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYM-0032
Application*: F
Target: MSR1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBFYM-0021
Application*: E, F, IF, IH, IP, WB
Target: MSR1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYM-0012
Application*: F
Target: MSR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: 7G5C33
Application*: WB
Target: MSR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 7C9C20
Application*: F
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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