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Mouse Anti-MSR1 Recombinant Antibody (CBXS-5969) (CBMAB-S0816-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5969
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 197-451 of human MSR1 (NP_619730)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Macrophage Scavenger Receptor 1
Introduction
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
Entrez Gene ID
4481
UniProt ID
P21757
Alternative Names
Macrophage Scavenger Receptor 1; Macrophage Acetylated LDL Receptor I And II; Scavenger Receptor Class A Member 1; SCARA1; Macrophage Scavenger Receptor Types I And II; Macrophage Scavenger Receptor Type III; CD204 Antigen; SR-AIII;
Function
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254).

Isoform III does not internalize acetylated LDL (PubMed:9548586).
Biological Process
Amyloid-beta clearance Source: ARUK-UCL
Cellular response to organic cyclic compound Source: Ensembl
Cholesterol transport Source: BHF-UCL
Lipoprotein transport Source: Ensembl
Negative regulation of gene expression Source: ARUK-UCL
Phagocytosis, engulfment Source: ARUK-UCL
Plasma lipoprotein particle clearance Source: BHF-UCL
Positive regulation of cholesterol storage Source: BHF-UCL
Positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
Receptor-mediated endocytosis Source: ARUK-UCL
Cellular Location
Membrane
Involvement in disease
Prostate cancer (PC):
A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
Barrett esophagus (BE):
A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.
Topology
Cytoplasmic: 1-50
Helical: 51-76
Extracellular: 77-451
More Infomation

Onyishi, C. U., Desanti, G. E., Wilkinson, A. L., Lara-Reyna, S., Frickel, E. M., Fejer, G., ... & May, R. C. (2023). Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen. Nature Communications, 14(1), 4895.

Baos, S., Cremades-Jimeno, L., López-Ramos, M., de Pedro, M. Á., Uriarte, S. A., Sastre, J., ... & Cárdaba, B. (2022). Expression of macrophage scavenger receptor (MSR1) in peripheral blood cells from patients with different respiratory diseases: Beyond monocytes. Journal of Clinical Medicine, 11(5), 1439.

Gudgeon, J., Marín-Rubio, J. L., & Trost, M. (2022). The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer. Frontiers in Immunology, 13, 1012002.

Govaere, O., Petersen, S. K., Martinez-Lopez, N., Wouters, J., Van Haele, M., Mancina, R. M., ... & Härtlova, A. (2022). Macrophage scavenger receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease. Journal of hepatology, 76(5), 1001-1012.

Sheng, W., Ji, G., & Zhang, L. (2022). Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis. Frontiers in Immunology, 13, 1050984.

Li, B., Chen, M., Aguzzi, A., & Zhu, C. (2021). The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis. Journal of Molecular Medicine, 99, 877-887.

Zheng, M., Tian, T., Liang, J., Ye, S., Chen, J., & Ji, Y. (2021). High-expressed macrophage scavenger receptor 1 predicts severity clinical outcome in transplant patient in idiopathic pulmonary fibrosis disease. Journal of Immunology Research, 2021.

Yang, L., Geng, T., Yang, G., Ma, J., Wang, L., Ketkar, H., ... & Wang, P. (2020). Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice. Communications Biology, 3(1), 556.

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For research use only. Not intended for any clinical use.

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