MESP1

MESP1 (Mesoderm Posterior BHLH Transcription Factor 1) is a Protein Coding gene. Diseases associated with MESP1 include Tricuspid Atresia and Heart Septal Defect. Among its related pathways are Cardiac Progenitor Differentiation. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is MESP2.

Full Name

Mesoderm Posterior BHLH Transcription Factor 1

Function

Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity).

Biological Process

Cardiac atrium formation Source: BHF-UCL
Cardiac cell fate determination Source: BHF-UCL
Cardiac muscle cell differentiation Source: BHF-UCL
Cardiac vascular smooth muscle cell differentiation Source: BHF-UCL
Cardiac ventricle formation Source: BHF-UCL
Cardioblast anterior-lateral migration Source: BHF-UCL
Cardioblast migration to the midline involved in heart field formation Source: BHF-UCL
Embryonic heart tube morphogenesis Source: BHF-UCL
Endothelial cell differentiation Source: BHF-UCL
Gastrulation Source: BHF-UCL
Gene expression Source: Ensembl
Growth involved in heart morphogenesis Source: BHF-UCL
Heart looping Source: BHF-UCL
Heart morphogenesis Source: GO_Central
Lateral mesoderm development Source: BHF-UCL
Mesodermal cell migration Source: Ensembl
Mesoderm formation Source: GO_Central
Negative regulation of endodermal cell fate specification Source: BHF-UCL
Negative regulation of mesodermal cell fate specification Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Neurogenesis Source: BHF-UCL
Notch signaling pathway Source: UniProtKB-KW
Positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
Positive regulation of hepatocyte differentiation Source: BHF-UCL
Positive regulation of Notch signaling pathway Source: BHF-UCL
Positive regulation of Notch signaling pathway involved in heart induction Source: Ensembl
Positive regulation of striated muscle cell differentiation Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Secondary heart field specification Source: BHF-UCL
Signal transduction involved in regulation of gene expression Source: Ensembl
Sinoatrial node cell differentiation Source: BHF-UCL
Sinus venosus morphogenesis Source: BHF-UCL
Somite rostral/caudal axis specification Source: GO_Central

Cellular Location

Nucleus