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Rabbit Anti-MESP1 (AA 1-85) Recombinant Antibody (CBFYM-0084) (CBMAB-M0095-FY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBFYM-0084
Antibody Isotype
IgG
Application
WB, FC, CyTOF

Basic Information

Immunogen
Partial recombinant human MESP-1 protein (amino acids 1-85)
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-85

Target

Full Name
Mesoderm Posterior BHLH Transcription Factor 1
Introduction
MESP1 is a Protein Coding gene. Diseases associated with MESP1 include Tricuspid Atresia and Heart Septal Defect. Among its related pathways are Cardiac Progenitor Differentiation. Gene Ontology annotations related to this gene include DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is MESP2.
Entrez Gene ID
Human55897
Mouse17292
UniProt ID
HumanQ9BRJ9
MouseP97309
Alternative Names
Mesoderm Posterior BHLH Transcription Factor 1; Mesoderm Posterior Basic Helix-Loop-Helix Transcription Factor 1; Class C Basic Helix-Loop-Helix Protein 5; BHLHc5; Mesoderm Posterior 1 Homolog (Mouse); Mesoderm Posterior 1 Homolog; Mesoderm Posterior Protein 1
Function
Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity).
Biological Process
Cardiac atrium formation Source: BHF-UCL
Cardiac cell fate determination Source: BHF-UCL
Cardiac muscle cell differentiation Source: BHF-UCL
Cardiac vascular smooth muscle cell differentiation Source: BHF-UCL
Cardiac ventricle formation Source: BHF-UCL
Cardioblast anterior-lateral migration Source: BHF-UCL
Cardioblast migration to the midline involved in heart field formation Source: BHF-UCL
Embryonic heart tube morphogenesis Source: BHF-UCL
Endothelial cell differentiation Source: BHF-UCL
Gastrulation Source: BHF-UCL
Gene expression Source: Ensembl
Growth involved in heart morphogenesis Source: BHF-UCL
Heart looping Source: BHF-UCL
Heart morphogenesis Source: GO_Central
Lateral mesoderm development Source: BHF-UCL
Mesodermal cell migration Source: Ensembl
Mesoderm formation Source: GO_Central
Negative regulation of endodermal cell fate specification Source: BHF-UCL
Negative regulation of mesodermal cell fate specification Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Neurogenesis Source: BHF-UCL
Notch signaling pathway Source: UniProtKB-KW
Positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
Positive regulation of hepatocyte differentiation Source: BHF-UCL
Positive regulation of Notch signaling pathway Source: BHF-UCL
Positive regulation of Notch signaling pathway involved in heart induction Source: Ensembl
Positive regulation of striated muscle cell differentiation Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Secondary heart field specification Source: BHF-UCL
Signal transduction involved in regulation of gene expression Source: Ensembl
Sinoatrial node cell differentiation Source: BHF-UCL
Sinus venosus morphogenesis Source: BHF-UCL
Somite rostral/caudal axis specification Source: GO_Central
Cellular Location
Nucleus
More Infomation

Krup, A. L., Winchester, S. A., Ranade, S. S., Agrawal, A., Devine, W. P., Sinha, T., ... & Bruneau, B. G. (2023). A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors. Development, 150(9), dev201229.

Ji, S., Xu, M., Cai, C., & He, X. (2023). MESP1-knockdown inhibits the proliferation and epithelial mesenchymal transition of hepatocellular carcinoma and enhances the tumor-suppressive effect of 5-fluorouracil. Biochemical and Biophysical Research Communications.

Lin, X., Swedlund, B., Ton, M. L. N., Ghazanfar, S., Guibentif, C., Paulissen, C., ... & Blanpain, C. (2022). Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors. Nature cell biology, 24(7), 1114-1128.

Liang, Q., Wang, S., Zhou, X., Li, Y., Xing, S., Yang, F., ... & Sun, N. (2022). Essential role of MESP1-RING1A complex in cardiac differentiation. Developmental Cell, 57(22), 2533-2549.

Ajima, R., Sakakibara, Y., Sakurai-Yamatani, N., Muraoka, M., & Saga, Y. (2021). Formal proof of the requirement of MESP1 and MESP2 in mesoderm specification and their transcriptional control via specific enhancers in mice. Development, 148(20), dev194613.

Haridhasapavalan, K. K., Ranjan, S. H., Bhattacharyya, S., & Thummer, R. P. (2021). Soluble expression, purification, and secondary structure determination of human MESP1 transcription factor. Applied Microbiology and Biotechnology, 105, 2363-2376.

Wang, L., Zhang, F., Duan, F., Huang, R., Chen, X., Ming, J., & Na, J. (2020). Homozygous MESP1 knock-in reporter hESCs facilitated cardiovascular cell differentiation and myocardial infarction repair. Theranostics, 10(15), 6898.

Tandon, N., Goller, K., Wang, F., Soibam, B., Gagea, M., Jain, A. K., ... & Liu, Y. (2019). Aberrant expression of embryonic mesendoderm factor MESP1 promotes tumorigenesis. EBioMedicine, 50, 55-66.

Eskildsen, T. V., Ayoubi, S., Thomassen, M., Burton, M., Mandegar, M. A., Conklin, B. R., ... & Sheikh, S. P. (2019). MESP1 knock-down in human iPSC attenuates early vascular progenitor cell differentiation after completed primitive streak specification. Developmental biology, 445(1), 1-7.

Penaloza, J. S., Pappas, M. P., Hagen, H. R., Xie, N., & Chan, S. S. (2019). Single-cell RNA-seq analysis of Mesp1-induced skeletal myogenic development. Biochemical and Biophysical Research Communications, 520(2), 284-290.

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For research use only. Not intended for any clinical use.

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