MAZ

MAZ (MYC Associated Zinc Finger Protein) is a Protein Coding gene. Among its related pathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is PATZ1.

MAZ

Transcriptional regulator, potentially with dual roles in transcription initiation and termination.

Isoform 1:
Binds DNA and functions as a transcriptional activator (PubMed:12270922).

Binds to two G/A-rich sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former (PubMed:1502157).

Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors (PubMed:1502157).

Isoform 2:
Binds DNA and functions as a transcriptional activator (PubMed:12270922).

Inhibits MAZ isoform 1-mediated transcription (PubMed:12270922).

Isoform 3:
Binds DNA and functions as a transcriptional activator.

Negative regulation of apoptotic signaling pathway Source: ARUK-UCL
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of cell migration Source: ARUK-UCL
Positive regulation of cell population proliferation Source: ARUK-UCL
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of phosphatidylinositol 3-kinase signaling Source: ARUK-UCL
Positive regulation of protein kinase B signaling Source: ARUK-UCL
Positive regulation of transcription, DNA-templated Source: ARUK-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Termination of RNA polymerase II transcription Source: UniProtKB
Transcription initiation from RNA polymerase II promoter Source: UniProtKB

Nucleus
Note: In brains of Alzheimer disease patients, present in a plaque-like structures.