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Mouse Anti-MAZ Recombinant Antibody (CBFYM-1777) (CBMAB-M1945-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1777
Antibody Isotype
IgG2b
Application
IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MAZ
Introduction
MAZ is a Protein Coding gene. Among its related pathways are Sudden Infant Death Syndrome Susceptibility Pathways. Gene Ontology annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is PATZ1.
Entrez Gene ID
4150
UniProt ID
P56270
Alternative Names
MYC Associated Zinc Finger Protein; Purine-Binding Transcription Factor; Transcription Factor Zif87; Zinc Finger Protein 801; ZNF801; Pur-1; SAF-1; MAZI; ZF87; MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor)
Function
Transcriptional regulator, potentially with dual roles in transcription initiation and termination.

Isoform 1:
Binds DNA and functions as a transcriptional activator (PubMed:12270922).

Binds to two G/A-rich sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former (PubMed:1502157).

Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors (PubMed:1502157).

Isoform 2:
Binds DNA and functions as a transcriptional activator (PubMed:12270922).

Inhibits MAZ isoform 1-mediated transcription (PubMed:12270922).

Isoform 3:
Binds DNA and functions as a transcriptional activator.
Biological Process
Negative regulation of apoptotic signaling pathway Source: ARUK-UCL
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of cell migration Source: ARUK-UCL
Positive regulation of cell population proliferation Source: ARUK-UCL
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of phosphatidylinositol 3-kinase signaling Source: ARUK-UCL
Positive regulation of protein kinase B signaling Source: ARUK-UCL
Positive regulation of transcription, DNA-templated Source: ARUK-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Termination of RNA polymerase II transcription Source: UniProtKB
Transcription initiation from RNA polymerase II promoter Source: UniProtKB
Cellular Location
Nucleus
Note: In brains of Alzheimer disease patients, present in a plaque-like structures.
More Infomation

Zheng, C., Wu, H., Zhang, S., Tian, R., Long, H., Zhang, H., ... & Zhu, X. (2023). Myc-Associated Zinc Finger Protein Promotes Metastasis of Papillary Thyroid Cancer. Frontiers in Bioscience-Landmark, 28(8), 162.

Zheng, C., Wu, H., Jin, S., Li, D., Tan, S., & Zhu, X. (2022). Roles of Myc‐associated zinc finger protein in malignant tumors. Asia‐Pacific Journal of Clinical Oncology, 18(6), 506-514.

Deen, D., Butter, F., Daniels, D. E., Ferrer-Vicens, I., Ferguson, D. C., Holland, M. L., ... & Vernimmen, D. (2021). Identification of the transcription factor MAZ as a regulator of erythropoiesis. Blood Advances, 5(15), 3002-3015.

Xiao, T., Li, X., & Felsenfeld, G. (2021). The Myc-associated zinc finger protein (MAZ) works together with CTCF to control cohesin positioning and genome organization. Proceedings of the National Academy of Sciences, 118(7), e2023127118.

Ren, L. X., Qi, J. C., Zhao, A. N., Shi, B., Zhang, H., Wang, D. D., & Yang, Z. (2021). Myc-associated zinc-finger protein promotes clear cell renal cell carcinoma progression through transcriptional activation of the MAP2K2-dependent ERK pathway. Cancer cell international, 21(1), 1-13.

Wang, Y., Sun, L., Qiu, W., Qi, W., Qi, Y., Liu, Z., ... & Lv, J. (2020). Inhibiting Forkhead box K1 induces autophagy to reverse epithelial-mesenchymal transition and metastasis in gastric cancer by regulating Myc-associated zinc finger protein in an acidic microenvironment. Aging (Albany NY), 12(7), 6129.

Xiao, T., Li, X., & Felsenfeld, G. (2020). The Myc-Associated Zinc Finger Protein (MAZ) Works Both Independently and Together with CTCF to Control Cohesin Positioning and Genome Organization. Available at SSRN 3549502.

Ortabozkoyun-Kara, H., Huang, P. Y., Cho, H., Narendra, V., Leroy, G., Skok, J. A., ... & Reinberg, D. (2020). A CRISPR screen identifies Myc-associated zinc finger protein (MAZ) as an insulator functioning at CTCF boundaries in Hox clusters. BioRxiv, 2020-08.

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For research use only. Not intended for any clinical use.

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