MAP4

The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

microtubule-associated protein 4

Non-neuronal microtubule-associated protein. Promotes microtubule assembly.

Cell divisionManual Assertion Based On ExperimentIMP:MGI
Establishment of spindle orientationManual Assertion Based On ExperimentIMP:MGI
Microtubule cytoskeleton organizationISS:ARUK-UCL
Microtubule slidingManual Assertion Based On ExperimentIMP:MGI
Mitotic spindle organizationManual Assertion Based On ExperimentIMP:MGI
Negative regulation of non-motile cilium assemblyManual Assertion Based On ExperimentIMP:GO_Central
Neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central

Cytoplasm, cytoskeleton
Cytoplasm, cytoskeleton, microtubule organizing center
Recruitment to microtubule is inhibited by microtubules polyglutamylation.

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity).
Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.