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Mouse Anti-MAP4 (AA 1-99) Recombinant Antibody (CBFYM-1545) (CBMAB-M1710-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1545
Antibody Isotype
IgG2a, k
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-99

Target

Full Name
microtubule-associated protein 4
Introduction
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein and microtubule-associated protein tau. This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
4134
UniProt ID
P27816
Alternative Names
Microtubule Associated Protein 4; MAP-4; Microtubule-Associated Protein 4
Function
Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
Biological Process
Cell divisionManual Assertion Based On ExperimentIMP:MGI
Establishment of spindle orientationManual Assertion Based On ExperimentIMP:MGI
Microtubule cytoskeleton organizationISS:ARUK-UCL
Microtubule slidingManual Assertion Based On ExperimentIMP:MGI
Mitotic spindle organizationManual Assertion Based On ExperimentIMP:MGI
Negative regulation of non-motile cilium assemblyManual Assertion Based On ExperimentIMP:GO_Central
Neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytoskeleton
Cytoplasm, cytoskeleton, microtubule organizing center
Recruitment to microtubule is inhibited by microtubules polyglutamylation.
PTM
Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity).
Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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