MAGED1

This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

MAGE Family Member D1

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.

Circadian regulation of gene expressionISS:UniProtKB
Negative regulation of epithelial cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein localization to nucleusIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of apoptotic signaling pathwayIEA:Ensembl
Positive regulation of branching involved in ureteric bud morphogenesisIEA:Ensembl
Positive regulation of MAP kinase activityIEA:Ensembl
Regulation of apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of circadian rhythmIEA:Ensembl
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB

Cytoplasm
Cell membrane
Nucleus
Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.