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Mouse Anti-MAGED1 (AA 117-226) Recombinant Antibody (CBFYM-1329) (CBMAB-M1488-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1329
Antibody Isotype
IgG2b, k
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: EMADIQVSAA AARPKSAFKV QNATTKGPNG VYDFSQAHNA KDVPNTQPKA AFKSQNATPK GPNAAYDFSQ AATTGELAAN KSEMAFKAQN ATTKVGPNAT YNFSQSLNAN
Specificity
Human
Antibody Isotype
IgG2b, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 117-226

Target

Full Name
MAGE Family Member D1
Introduction
This gene is a member of the melanoma antigen gene family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene.
Entrez Gene ID
9500
UniProt ID
Q9Y5V3
Alternative Names
MAGE Family Member D1; Neurotrophin Receptor-Interacting MAGE Homolog; Melanoma Antigen Family D1; MAGE Tumor Antigen CCF; MAGE-D1 Antigen; NRAGE; Melanoma-Associated Antigen D1; Melanoma Antigen Family D, 1; DLXIN-1
Function
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
Biological Process
Circadian regulation of gene expressionISS:UniProtKB
Negative regulation of epithelial cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of protein localization to nucleusIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of apoptotic signaling pathwayIEA:Ensembl
Positive regulation of branching involved in ureteric bud morphogenesisIEA:Ensembl
Positive regulation of MAP kinase activityIEA:Ensembl
Regulation of apoptotic processManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of circadian rhythmIEA:Ensembl
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Cytoplasm
Cell membrane
Nucleus
Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.
More Infomation

Cheron, J., Beccari, L., Hagué, P., Icick, R., Despontin, C., Carusone, T., ... & de Kerchove d’Exaerde, A. (2023). USP7/Maged1-mediated H2A monoubiquitination in the paraventricular thalamus: an epigenetic mechanism involved in cocaine use disorder. Nature communications, 14(1), 8481.

Wang, J., Xu, S. Y., Ye, Z. Y., Sun, Z. N., Zhang, J. Q., Qi, C., ... & Gao, J. (2023). The deficiency of Maged1 attenuates Parkinson's disease progression in mice. Molecular Brain, 16(1), 1-16.

Park, S., Kwon, W., Kim, H. Y., Ji, Y. R., Kim, D., Kim, W., ... & Choi, S. K. (2022). Knockdown of Maged1 inhibits cell cycle progression and causes cell death in mouse embryonic stem cells. Differentiation, 125, 18-26.

Cheron, J., Beccari, L., Hagué, P., Icick, R., Despontin, C., Carusone, T., ... & de Kerchove d’Exaerde, A. (2022). USP7/Maged1-Mediated H2A Monoubiquitination in the Paraventricular Thalamus: An Epigenetic Mechanism Involved in Cocaine Use Disorder. bioRxiv, 2022-11.

Hu, L., Wang, J., Huang, H., Yu, Y., Ding, J., Yu, Y., ... & Chen, F. (2021). YTHDF1 regulates pulmonary hypertension through translational control of MAGED1. American journal of respiratory and critical care medicine, 203(9), 1158-1172.

Zhang, B., Li, D., Jin, X., & Zhang, K. (2020). The CDK4/6 inhibitor PD0332991 stabilizes FBP1 by repressing MAGED1 expression in pancreatic ductal adenocarcinoma. The International Journal of Biochemistry & Cell Biology, 128, 105859.

Wang, J., You, W. Y., Ye, Q., Zhang, J. Q., He, C., Qi, C., ... & Gao, J. (2020). The Deficiency of Maged1 Attenuates Parkinson's Disease Progression by Inhibiting Apoptosis and Enhancing Autophagy in Mice.

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For research use only. Not intended for any clinical use.

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