M6PR

This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X.

M6PR

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

Endosome to lysosome transportManual Assertion Based On ExperimentTAS:ProtInc
Lysosomal transportISS:UniProtKB
Protein targeting to lysosomeManual Assertion Based On ExperimentIBA:GO_Central
Receptor-mediated endocytosisManual Assertion Based On ExperimentTAS:ProtInc
Secretion of lysosomal enzymesIEA:Ensembl

Lysosome membrane

Lumenal: 27-185
Helical: 186-210
Cytoplasmic: 211-277