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Rabbit Anti-M6PR Recombinant Antibody (CBFYM-0313) (CBMAB-M0378-FY)


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Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBFYM-0313
Antibody Isotype
IgG
Application
WB, IP, IHC-P, FC, IF

Basic Information

Immunogen
Recombinant protein
Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
M6PR
Introduction
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X.
Entrez Gene ID
Human4074
Mouse17113
Rat312689
UniProt ID
HumanP20645
MouseP24668
RatQ6AY20
Alternative Names
Mannose-6-Phosphate Receptor, Cation Dependent; CD Man-6-P Receptor; MPR 46; CD-MPR; MPR46; Mannose-6-Phosphate Receptor (Cation Dependent); Cation-Dependent Mannose-6-Phosphate Receptor; 46-KDa Mannose 6-Phosphate Receptor
Function
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
Biological Process
Endosome to lysosome transportManual Assertion Based On ExperimentTAS:ProtInc
Lysosomal transportISS:UniProtKB
Protein targeting to lysosomeManual Assertion Based On ExperimentIBA:GO_Central
Receptor-mediated endocytosisManual Assertion Based On ExperimentTAS:ProtInc
Secretion of lysosomal enzymesIEA:Ensembl
Cellular Location
Lysosome membrane
Topology
Lumenal: 27-185
Helical: 186-210
Cytoplasmic: 211-277
More Infomation

Gauthier, C., El Cheikh, K., Basile, I., Daurat, M., Morère, E., Garcia, M., ... & Gary-Bobo, M. (2024). Cation-independent mannose 6-phosphate receptor: From roles and functions to targeted therapies. Journal of Controlled Release, 365, 759-772.

Liu, D., Huang, R., Yuan, K., Zhao, J., Wang, Z., Yi, Q., & Wang, J. (2023). Molecular characterization of a cation-dependent mannose-6-phosphate receptor gene in Crassostrea hongkongensis and its responsiveness in Vibrio alginolyticus infection. Fish & Shellfish Immunology, 139, 108843.

Yu, J., Li, H., Fang, T., Yun, C., Liu, X., Xu, J., ... & Cai, X. (2023). Harnessing the lysosomal sorting signals of the cation-independent mannose-6-phosphate receptor for targeted degradation of membrane proteins. Journal of the American Chemical Society, 145(34), 19107-19119.

Gauthier, C., Mariot, J., Daurat, M., Dhommée, C., El Cheikh, K., Morère, E., ... & Maynadier, M. (2023). Mannose 6-phosphate receptor-targeting antibodies preserve Fc receptor-mediated recycling. Journal of Controlled Release, 358, 465-475.

Frustaci, A., Verardo, R., Scialla, R., Bagnato, G., Verardo, M., Alfarano, M., & Russo, M. A. (2022). Downregulation of mannose-6-phosphate receptors in fabry disease cardiomyopathy: A potential target for enzyme therapy enhancement. Journal of Clinical Medicine, 11(18), 5440.

Liang, X. H., Nichols, J. G., Hsu, C. W., & Crooke, S. T. (2021). Hsc70 facilitates mannose-6-phosphate receptor-mediated intracellular trafficking and enhances endosomal release of phosphorothioate-modified antisense oligonucleotides. nucleic acid therapeutics, 31(4), 284-297.

Daurat, M., Nguyen, C., Gil, S. D., Sol, V., Chaleix, V., Charnay, C., ... & Gary-Bobo, M. (2020). The mannose 6-phosphate receptor targeted with porphyrin-based periodic mesoporous organosilica nanoparticles for rhabdomyosarcoma theranostics. Biomaterials science, 8(13), 3678-3684.

Kanzaki, M., Tsukimura, T., Chiba, Y., Sakuraba, H., & Togawa, T. (2020). Surface plasmon resonance analysis of complex formation of therapeutic recombinant lysosomal enzymes with domain 9 of human cation-independent mannose 6-phosphate receptor. Molecular Genetics and Metabolism Reports, 25, 100639.

Dwyer, B., Lundberg, D., Iskenderian, A., Strack-Logue, B., Pescatore, B., Norton, A. W., ... & Zhang, B. (2020). Expression, purification, and characterization of human mannose-6-phosphate receptor–Extra cellular domain from a stable cell line utilizing a small molecule biomimetic of the mannose-6-phosphate moiety. Protein Expression and Purification, 170, 105589.

Girsch, J. H., Jackson, W., Carpenter, J. E., Moninger, T. O., Jarosinski, K. W., & Grose, C. (2020). Exocytosis of progeny infectious varicella-zoster virus particles via a mannose-6-phosphate receptor pathway without xenophagy following secondary envelopment. Journal of virology, 94(16), 10-1128.

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For research use only. Not intended for any clinical use.

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