LRPAP1

This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants.

LDL receptor related protein associated protein 1

Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.

Amyloid-beta clearance by transcytosisManual Assertion Based On ExperimentIMP:ARUK-UCL
Extracellular negative regulation of signal transductionManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Negative regulation of amyloid-beta clearanceManual Assertion Based On ExperimentIGI:BHF-UCL
Negative regulation of cell deathManual Assertion Based On ExperimentIGI:ARUK-UCL
Negative regulation of protein bindingManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of receptor internalizationManual Assertion Based On ExperimentIGI:ARUK-UCL
Negative regulation of very-low-density lipoprotein particle clearanceManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of amyloid-beta clearanceManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of receptor-mediated endocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentIDA:UniProtKB

Rough endoplasmic reticulum lumen
Endoplasmic reticulum-Golgi intermediate compartment lumen
Golgi apparatus, cis-Golgi network
Golgi apparatus lumen
Endosome lumen
Cell surface
May be associated with receptors at the cell surface.

Myopia 23, autosomal recessive (MYP23):
A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far.

N-glycosylated.