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Mouse Anti-LRPAP1 Recombinant Antibody (34) (CBMAB-L2082-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
34
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant Human LRPAP1 protein.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LDL receptor related protein associated protein 1
Introduction
LRPAP1 interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
4043
UniProt ID
P30533
Alternative Names
RAP; MRAP; A2RAP; HBP44; MYP23; A2MRAP; alpha-2-MRAP; alpha-2-macroglobulin receptor-associated protein; 39 kDa receptor-associated protein; low density lipoprotein receptor-related protein associated protein 1; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)
Function
Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.
Biological Process
Amyloid-beta clearance by transcytosisManual Assertion Based On ExperimentIMP:ARUK-UCL
Extracellular negative regulation of signal transductionManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Negative regulation of amyloid-beta clearanceManual Assertion Based On ExperimentIGI:BHF-UCL
Negative regulation of cell deathManual Assertion Based On ExperimentIGI:ARUK-UCL
Negative regulation of protein bindingManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of receptor internalizationManual Assertion Based On ExperimentIGI:ARUK-UCL
Negative regulation of very-low-density lipoprotein particle clearanceManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of amyloid-beta clearanceManual Assertion Based On ExperimentTAS:ARUK-UCL
Regulation of receptor-mediated endocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Rough endoplasmic reticulum lumen
Endoplasmic reticulum-Golgi intermediate compartment lumen
Golgi apparatus, cis-Golgi network
Golgi apparatus lumen
Endosome lumen
Cell surface
May be associated with receptors at the cell surface.
Involvement in disease
Myopia 23, autosomal recessive (MYP23):
A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far.
PTM
N-glycosylated.
More Infomation

Li, H., Wang, X., Wang, Y., Li, Y., Chen, Y., Wong, Y. T., ... & He, M. L. (2023). Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity. Signal Transduction and Targeted Therapy, 8(1), 374.

Reid, K. M., & Brown, G. C. (2023). LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation. Frontiers in Immunology, 14.

Liu, S., Chen, T., Chen, B., Liu, Y., Lu, X., & Li, J. (2022). Lrpap1 deficiency leads to myopia through TGF-β-induced apoptosis in zebrafish. Cell Communication and Signaling, 20(1), 162.

Podgórska, D., Cieśla, M., Majdan, M., Podgórski, R., & Kolarz, B. (2021). The relationship of ADAMTSL2 and LRPAP1 gene methylation level with rheumatoid arthritis activity. Clinical and Experimental Rheumatology.

Thurner, L., Fadle, N., Bittenbring, J. T., Regitz, E., Schuck, R., Cetin, O., ... & Hoster, E. (2021). LRPAP1 autoantibodies in mantle cell lymphoma are associated with superior outcome. Blood, The Journal of the American Society of Hematology, 137(23), 3251-3258.

Bewarder, M., Kiefer, M., Will, H., Olesch, K., Moelle, C., Stilgenbauer, S., ... & Thurner, L. (2021). The B-cell receptor autoantigen LRPAP1 can replace variable antibody regions to target mantle cell lymphoma cells. HemaSphere, 5(8).

Sumazaki, M., Shimada, H., Ito, M., Shiratori, F., Kobayashi, E., Yoshida, Y., ... & Hiwasa, T. (2020). Serum anti‐LRPAP1 is a common biomarker for digestive organ cancers and atherosclerotic diseases. Cancer science, 111(12), 4453-4464.

Magliyah, M. S., Alsulaiman, S. M., Nowilaty, S. R., Alkuraya, F. S., & Schatz, P. (2020). Rhegmatogenous retinal detachment in nonsyndromic high myopia associated with recessive mutations in LRPAP1. Ophthalmology Retina, 4(1), 77-83.

Thurner, L., Hartmann, S., Fadle, N., Kemele, M., Bock, T., Bewarder, M., ... & Pfreundschuh, M. (2019). LRPAP1 is a frequent proliferation-inducing antigen of BCRs of mantle cell lymphomas and can be used for specific therapeutic targeting. Leukemia, 33(1), 148-158.

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For research use only. Not intended for any clinical use.

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